New bioceramic root‑canal medicine for reducing pain after treatment of infected upper front teeth
Impact of a New Bioceramic Based Intracanal Medication on Postoperative Pain and Periapical Healing
This trial will try a new bioceramic intracanal medicine (BIO-C® TEM) to see if it reduces post‑operative pain and improves healing in adults with infected upper front teeth (periapical periodontitis).
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Trial ID | NCT07075055 on ClinicalTrials.gov |
What this trial studies
The trial compares a new bioceramic intracanal medicament (BIO-C® TEM) with a traditional calcium hydroxide paste (Metapaste) used between root canal appointments for maxillary anterior teeth with periapical periodontitis. Patients with mature upper front teeth and no systemic conditions that affect healing will receive standard endodontic cleaning and then one of the two intracanal medications placed between visits. Pain levels and signs of periapical healing will be recorded over a follow‑up period, including a planned one‑year check. The goal is to determine whether the bioceramic product reduces post‑operative pain and promotes tissue healing better than the conventional option.
Who should consider this trial
Good fit: Adults with mature maxillary anterior teeth diagnosed with periapical periodontitis who are otherwise healthy, not pregnant, and willing to attend a one‑year follow‑up are ideal candidates.
Not a fit: Patients with immature roots, active swelling, systemic diseases affecting healing, periodontal involvement, vertical root fractures, non‑restorable teeth, prior endodontic treatment, elderly patients, or pregnant women are unlikely to qualify or benefit.
Why it matters
Potential benefit: If successful, the bioceramic medication could reduce post‑treatment pain and speed or improve periapical healing, lowering the chance of retreatment.
How similar studies have performed: Bioceramic endodontic materials have shown promising antimicrobial and healing properties in laboratory and early clinical reports, but long‑term randomized comparisons with calcium hydroxide are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with mature teeth. * Patients with periapical periodontitis. * Maxillary anterior teeth only will be involved. * Patients should be free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent and will commit to follow-up period Exclusion Criteria: * Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with swelling. * Pregnant females. * Patients who could/would not participate in a 1-year follow-up. * Patients with old age. * Teeth with periodontal involvement. * Teeth with vertical root fractures. * Non-restorable teeth. * Cases with previously initiated endodontic treatment.
Where this trial is running
Minya
- Minia University, Faculty of Dentistry — Minya, Egypt (Recruiting)
Study contacts
- Study coordinator: Hanaa Ewas Korany Mabrouk, M.D
- Email: Dentist77789@gmail.com
- Phone: +201141265954
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.