Network for research on primary spine tumors
Primary Tumor Research and Outcomes Network (PTRON) A Multicenter Prospective Registry for the Management and Outcomes of Primary Tumors of the Spine
This study is trying to gather information from different spine cancer centers to see how well treatments work and how they affect patients' lives.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1350 (estimated) |
| Sex | All |
| Sponsor | AO Innovation Translation Center Academic / other |
| Locations | 19 sites (Los Angeles, California and 18 other locations) |
| Trial ID | NCT02790983 on ClinicalTrials.gov |
What this trial studies
This project establishes a network of spine oncology centers to conduct prospective multicenter research on patients diagnosed with primary spinal column tumors. It aims to create a comprehensive clinical database that collects demographic, clinical, diagnostic, and therapeutic variables. The data will be used to investigate survival rates, local recurrence, morbidity, and health-related quality of life outcomes. By analyzing these variables, the study seeks to enhance understanding of treatment impacts and patient experiences.
Who should consider this trial
Good fit: Ideal candidates include patients currently diagnosed with or having a history of primary spinal tumors.
Not a fit: Patients diagnosed with metastatic tumors of the spine will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies and outcomes for patients with primary spinal tumors.
How similar studies have performed: Other studies focusing on registry-based approaches for cancer outcomes have shown promise, indicating potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria * Patient with a current primary spine tumor or history of a primary spine tumor, including tumors within or surrounding the spinal column and/or spinal cord. This includes extradural tumors, intramedullary tumors (i.e. astrocytomas, ependymoma, etc.) and extramedullary tumors (i.e. meningiomas, neurofibromas, schwannomas, etc.). * Informed consent obtained, i.e.: * Ability to understand the content of the patient information/ICF * Willingness and ability to participate in the registry according to the Registry Plan (RP) * Signed and dated EC/IRB approved written informed consent OR * Written consent provided according to the IRB/EC defined and approved procedures for patients who are not able to provide independent written informed consent Exclusion Criteria: \- Patient diagnosed with a metastatic tumor of the spine.
Where this trial is running
Los Angeles, California and 18 other locations
- University of California — Los Angeles, California, United States (Terminated)
- UCSF Medical Center — San Francisco, California, United States (Recruiting)
- Johns Hopkins University School of Medicine — Baltimore, Maryland, United States (Recruiting)
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States (Withdrawn)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (Recruiting)
- Rhode Island Hospital — Providence, Rhode Island, United States (Recruiting)
- The University of Texas M.D. Anderson Cancer Center — Houston, Texas, United States (Recruiting)
- University of Queensland, School of Medicine — Brisbane, Australia (Withdrawn)
- Vancouver General Hospital and the University of British Columbia — Vancouver, British Columbia, Canada (Recruiting)
- Toronto Western Hospital — Toronto, Ontario, Canada (Terminated)
- Peking University 3rd Hospital — Beijing, Beijing Municipality, China (Recruiting)
- Universitaetsklinikum Carl Gustav Carus der Techn. Universitaet - Dresden — Dresden, Germany (Recruiting)
- National Center for Spinal Disorders and Buda Health Center — Budapest, Hungary (Recruiting)
- Istituto Ortopedico Rizzoli — Bologna, Italy (Recruiting)
- IRCCS Istituto Ortopedico Galeazzi — Milan, Italy (Recruiting)
- Kanazawa Medical University Hospital — Kanazawa, Japan (Terminated)
- Oxford University Hospitals — Oxford, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Jeremy Reynolds, MD — Clinical Lead for Spinal Surgery at Oxford University Hospitals
- Study coordinator: Felix Thomas, PhD
- Email: felix.thomas@aofoundation.org
- Phone: +41 79 671 47 98
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.