NESA neuromodulation versus posterior tibial nerve stimulation for overactive bladder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Twenty-four women aged 38–85 with overactive bladder will receive ten sessions of non-invasive neuromodulation delivered twice weekly, with participants assigned to either NESA neuromodulation or transcutaneous posterior tibial nerve stimulation. Each session includes same-day exercises and patient education, and outcomes collected will include symptom scores, quality of life, discomfort, and sleep measures. The interventions are applied externally and exclude patients with contraindications such as pacemakers, pregnancy, recent infections, or certain neurological conditions. The study will compare changes over the treatment course to determine which non-invasive approach produces greater symptom and quality-of-life improvements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Minimum criteria for a primary diagnosis of overactive bladder who have or have not received active/alternative treatments for this pathology.
* Patients with previous pharmacological treatments that have not obtained an adequate clinical response.
* Patients whose cognitive abilities are competent to participate in the study and are able to complete the study questionnaires and have given written consent to participate in the study.
* Without further contraindications for electrotherapy treatment such as serious use of pacemakers, pregnancy, internal bleeding, poor skin condition (ulcerations, wounds...) and/or phobia of electricity.

Exclusion Criteria:

* Presence of urinary fistula.
* Infections in the last 12 months.
* Haematuria during the trial period.
* Pregnancy or plans to become pregnant during the study.
* Pathology of the central or peripheral nervous system (multiple sclerosis, Parkinson's disease, etc.).
* Uncontrolled diabetes.
* Currently treated with Botox injections for the bladder or within the last year.
* Current treatment with interstim or currently implanted interstim device.
* Bladder outlet obstruction.
* Urinary retention.
* Treatment with more than two antidepressants and/or multiple benzodiazepines, as well as antiepileptics.
* Contraindications for electrotherapy treatment.

Where it's running

• University of Valencia
  Valencia, Spain Recruiting

Study contacts

• Principal investigator: Paloma Blasco-Sonora, Physical Therapy — University of Valencia
• Study coordinator: Raquel I Medina-Ramírez, PhD. Physiotherapist
• Email: raquel.medina@ulpgc.es
• Phone: 0034 665265685

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.