Nerve grafting technique to help preserve erectile function after prostate surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial evaluates the safety and effectiveness of a novel nerve grafting technique during robotic-assisted laparoscopic radical prostatectomy in patients with high-risk localized prostate cancer. A total of 10 patients will undergo surgery using the nerve restoring approach, which incorporates a genitofemoral nerve graft aimed at improving erectile function recovery post-surgery. Patients will be assessed for erectile function and pain using standardized questionnaires at multiple follow-up points over 18 months. The study aims to minimize complications while enhancing recovery outcomes for erectile function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing standard of care robotic radical prostatectomy for high-risk localized prostate cancer as defined by any of:

   1. Gleason grade ≥8
   2. PSA ≥20
   3. \>pT2 on preoperative MRI imaging
2. Patients must have preoperative erectile function with a baseline IIEF score of ≥17

Exclusion Criteria:

1. Patients with previous pelvic surgery
2. Patients with previous pelvic radiotherapy
3. Patient with previous focal therapy for prostate cancer
4. Patients aged \< 18 years at diagnosis
5. Legally incapable patients
6. Patients who are unable to complete questionnaires and have no companion to help complete them
7. Patients undergoing a concomitant cancer surgery
8. Patients with pre-existing neurologic disease

Where it's running

• Jewish General Hospital, CIUSSS Centre-Ouest de l'île de Montréal
  Montreal, Quebec, Canada Recruiting
• Jewish General Hospital
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Victor McPherson, MD — Jewish General Hospital
• Study coordinator: Victor McPherson, MD
• Email: victor.mcpherson@mcgill.ca
• Phone: 514-340-8222

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Rehabilitation and Sex Therapy to Improve Recovery After Prostate Cancer Treatment

  This study tests whether adding telehealth sex therapy to pelvic floor physical therapy helps men recover sexual function after prostate cancer treatment.

  Recruiting Duke University · Durham, North Carolina · NCT07685249

• Stem cells to help erectile function after prostate surgery

  This phase 1/2 study tests whether injected stem cells can help men recover erectile function after radical prostatectomy for localized prostate cancer, compared to placebo.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT07048314

• Nerve-sparing prostate surgery using micro-ultrasound guidance

  This study is testing a new approach to prostate surgery that uses advanced ultrasound technology to help men with localized prostate cancer keep their sexual function while effectively removing the cancer.

  Recruiting Phase 3 Icahn School of Medicine at Mount Sinai · New York, New York · NCT06945315

• Helping men recover sexual function after prostate cancer surgery

  This study tests two different ways to help men regain their sexual function after prostate cancer surgery to see which one works better.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT02706561

• HIP2602 for Erectile Dysfunction: Testing a new treatment in adults

  This study tests whether HIP2602, alone or with related formulations, can improve erectile function in adult men with long-standing erectile dysfunction who partner with the same adult female partner.

  Recruiting Phase 3 Hanmi Pharmaceutical Company Limited · Busan · NCT07899073

• Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519

  This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.

  Recruiting at 2 sites Phase 1 Aktis Oncology, Inc. · Miami, Florida and 1 other locations · NCT07887971

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.