Nerve block injections for chronic jaw (TMJ) pain
Official title: Treatment of Chronic Temporomandibular Pain With Peripheral Nerve Block
Run by Bnai Zion Medical Center · NCT06966557 · Data updated 2026-11-12
Doctors will try nerve block injections to see if they reduce long-term jaw pain in adults with chronic TMJ who haven't improved after at least two other treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Bnai Zion Medical Center Government |
| Locations | 1 site (Haifa, North) |
| Status | Recruiting |
| Started | April 25, 2025 |
| Main results expected | May 2026 |
| Study ends | July 2026 |
| Registry record updated | June 10, 2025 |
| Trial ID | NCT06966557 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with chronic TMJ pain lasting 12 months or more who have tried and not benefited from at least two prior treatments, are mentally competent, and are not pregnant.
✕Probably not a fit
People with recent-onset TMJ pain, those who have not yet tried standard therapies, pregnant patients, or those unable to attend required follow-up visits are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational project follows adults with chronic temporomandibular joint (TMJ) pain who receive peripheral nerve block injections as part of routine care at a TMJ clinic. Providers inject local anesthetic near nerves that carry pain from the TMJ region, then patients return for scheduled follow-up visits to record pain levels and jaw function. Participants must have had TMJ pain for at least 12 months and have failed at least two prior treatment approaches. The study collects outcome data without changing the clinical treatment plan to characterize how often and how long patients experience relief.
Why it matters
Potential benefit: If successful, this approach could offer longer-lasting pain relief and improved jaw function for people whose TMJ pain hasn't responded to standard treatments.
How similar studies have gone: Peripheral nerve blocks are already used in practice and small case series report pain relief, but large controlled trials for chronic TMD are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (non-pregnant) with sound judgment * Chronic TMJ pain lasting at least 12 months * Documented failure of at least two previous treatment modalities Exclusion Criteria: * not meeting inclusion criteria * Missing at least two follow-up visits within the specified timeframe
Where it's running
-
Department of Oral and Maxillofacial Surgery
Haifa, North, Israel Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.