NEPTUNE Match: Personalized matching of patients to kidney treatment options

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

NEPTUNE Match is a prospective, open-label effort that recruits participants from the NEPTUNE observational cohort and creates patient-specific trial match assessments using existing clinical and molecular data reviewed by the NEPTUNE Molecular Nephrology Board. The program will establish and test a communication framework to share disease-to-drug-mechanism matches with treating clinicians and patients. It will then compare kidney health outcomes retrospectively between subjects who enrolled in trials aligned with their match and those with misaligned or unknown match alignment. The goal is to determine if structured matching and targeted communication improves trial alignment and downstream outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Consented and eligible participants in the biopsied or non-biopsied cohorts of the NEPTUNE observational study
2. Must be potentially eligible for the NEPTUNE Match partnering trials (e.g. if no trial is enrolling a participant under age 6, those under 6 are not eligible).

   Note: NEPTUNE Match partnering trials and associated eligibility criteria are expected to be dynamic and change as trial protocols are developed, activated, and amended.
3. Regular nephrology healthcare provided at a NEPTUNE study site.
4. Willing and able to consent, and as appropriate assent, to participate in NEPTUNE Match

Exclusion Criteria:

Currently non-NEPTUNE observational study participants are not eligible to be matched to a clinical trial using these biomarker assessments.

Exclusion Criteria:

1\. Non-English or non-Spanish speaking

Where it's running

• Emory University Hospital - Children's Hospital of Atlanta
  Atlanta, Georgia, United States Recruiting
• John H. Stroger, Jr., Hospital of Cook County
  Chicago, Illinois, United States Recruiting
• University of Kansas Medical Center
  Kansas City, Kansas, United States Recruiting
• Johns Hopkins Medicine
  Baltimore, Maryland, United States Recruiting
• Children's Mercy Hospital
  Kansas City, Missouri, United States Recruiting
• Northwell/Cohen's Children's Hospital
  New Hyde Park, New York, United States Recruiting

Study contacts

• Principal investigator: Matthias Kretzler, MD — University of Michigan
• Study coordinator: Hailey E Desmond, MS
• Email: heturner@med.umich.edu
• Phone: 734-232-4851

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.