Nebulized neostigmine/atropine versus nebulized lidocaine for post-dural puncture headache after cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, randomized interventional early phase I trial enrolls parturients who develop post-dural puncture headache after elective cesarean section under spinal anesthesia. Eligible women (aged 18–35) with moderate-to-severe headache (VAS ≥4 and Lybecker score ≥2) are randomized to receive nebulized neostigmine/atropine or nebulized lidocaine (total 4 ml). Headache intensity, need for rescue analgesia, and adverse events are followed after treatment to compare symptom relief and safety. The trial is conducted at Minia University and focuses on short-term headache outcomes and tolerability of the inhaled interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-35 years old parturient with post partum headache after elective CS under spinal anesthesia with visual analog score (VAS) ≥ 4 \[14\] and Lybecker classification score ≥ 2

Exclusion Criteria:

* Pregnancy induced hypertension
* Emergency C.S
* Asthmatic candidates
* Previous history of migraine or trigeminal neuralgia
* History of bronchial asthma
* Post partum hemorrhage
* Need for GA , failed spinal anesthesia
* Patient refusal

Where it's running

• Minia University
  Minya, Egypt Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.