Nd: YAG Laser treatment for moderate to severe periodontitis
the Clinical Effect of Nd: YAG Laser Assisted Periodontal Initial Therapy in Patients With Moderate to Severe Periodontitis: a Split-mouth, Randomized, Controlled Clinical Trial
This study is testing if laser treatment can help people with moderate to severe gum disease feel better compared to standard dental cleaning methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 22 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06587334 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of Neodymium-Doped Yttrium Aluminum Garnet (Nd: YAG) Laser-assisted non-surgical periodontal treatment in patients with stage II/III periodontitis. Participants will receive laser treatment on one side of their mouth and standard scaling and root planing (SRP) on the other side, allowing for a direct comparison of outcomes. The study will assess changes in probing depth, gingival inflammation, and clinical attachment loss, as well as measure inflammatory markers and oxidative stress levels. Follow-up assessments will occur at baseline, 6 weeks, and 3 months post-treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 diagnosed with stage II or III periodontitis.
Not a fit: Patients with fewer than 20 remaining teeth or those who have had recent periodontal treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective non-surgical option for managing moderate to severe periodontitis.
How similar studies have performed: Other studies have shown promising results with laser-assisted periodontal therapies, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years, with no gender restrictions. * Diagnosed with stage II or III periodontitis according to the 2018 Classification of Periodontal and Peri-Implant Diseases and Conditions. * In each of the four quadrants of the oral cavity, at least one tooth must have at least one site with a probing depth ≥5 mm, clinical attachment loss ≥2 mm, and bleeding on probing. * Participants must provide informed consent and sign the informed consent form. Exclusion Criteria: * Fewer than 20 remaining teeth (10 pairs of opposing teeth) or a significant discrepancy in the number of remaining teeth between the left and right sides of the mouth. * Patients who have undergone periodontal treatment within the past six months or are currently undergoing orthodontic treatment, which may affect periodontal health. * Patients with systemic diseases that could influence the outcomes of periodontal treatment. * Patients with severe infections, malignancies, or other major diseases affecting overall health. * Pregnant or breastfeeding women. * Individuals with a history of smoking. * Patients who are unable to comply with or complete periodontal treatment.
Where this trial is running
Hangzhou, Zhejiang
- The Second Affiliated Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: Jingyi Tan, Doctor — Second Affiliated Hospital, School of Medicine, Zhejiang University
- Study coordinator: Jingyi Tan, Doctor
- Email: tanjingyi@zju.edu.cn
- Phone: 15967121069
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.