Natural history of COVID-19 in hospitalized adults
Official title: Observational Cohort Study on the Natural History of Hospitalized SARS-COV-2 Patients: the STORM Trial
Run by University of Milano Bicocca · NCT04424992 · Data updated 2026-11-12
This project will follow adults hospitalized with COVID-19 to see how the illness and treatments change over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1433 (estimated) |
| Sponsor | University of Milano Bicocca Academic / other |
| Locations | 1 site (Monza) |
| Status | Recruiting |
| Started | February 28, 2020 |
| Main results expected | December 28, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | July 25, 2025 |
| Trial ID | NCT04424992 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) hospitalized with clinical or radiological evidence of lung infection and a laboratory-confirmed positive SARS‑CoV‑2 test are ideal candidates.
✕Probably not a fit
Children under 18, non-hospitalized patients, or people without a confirmed positive SARS‑CoV‑2 test are not eligible and would not benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study prospectively collects clinical, diagnostic, therapeutic, and laboratory data from adults hospitalized with SARS‑CoV‑2 infection using an eCRF on the REDCap platform. Data are organized in a 'stem and leaf' database structure aligned with WHO pandemic data recommendations, with a core dataset and optional 'leaf' modules for specific protocols. The intent is to describe disease course, identify risk strata for fatal events, and inform real-world therapeutic procedures. Enrollment is limited to patients aged 18 and over with clinical or radiological evidence of COVID‑19 and a positive SARS‑CoV‑2 test at the participating center.
Why it matters
Potential benefit: If successful, the data could help clinicians predict which hospitalized patients are at higher risk and refine treatment pathways to reduce complications and deaths.
How similar studies have gone: Numerous observational cohorts worldwide have already described the natural history of hospitalized COVID‑19 patients and contributed to risk stratification, so this approach builds on established methods.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinical and / or radiological diagnosis of lung infection with COVID-19; 2. Positive test for SARS-CoV-2 infection. Exclusion Criteria: 1\. Age less than 18 years
Where it's running
-
ASST Monza-Ospedale San Gerardo
Monza, Italy Recruiting
Study contacts
- Study coordinator: Paolo Bonfanti
- Email: paolo.bonfanti@unimib.it
- Phone: +39 039 233 9310
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Home-based exercise program for Veterans recovering from COVID-19
This study tests whether a home-based exercise program can help Veterans who have recovered from COVID-19 improve their heart and lung health and physical abilities.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.