National database for Giant Cell Arteritis and Polymyalgia Rheumatica
Official title: Disease Stratification in GCA and PMR to Inform Management and Reduce Disease and Treatment-related Damage
Run by University of Aarhus · NCT05935709 · Data updated 2026-11-12
This study is trying to see how new imaging techniques can help doctors better manage Giant Cell Arteritis and Polymyalgia Rheumatica by looking at treatment responses and risks in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Locations | 2 sites (Aarhus and 1 other locations) |
| Status | Recruiting |
| Started | November 10, 2023 |
| Main results expected | December 31, 2034 |
| Study ends | December 31, 2051 |
| Registry record updated | January 24, 2024 |
| Trial ID | NCT05935709 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with GCA or PMR within the last five years who can provide informed consent and speak Danish.
✕Probably not a fit
Patients with other systemic autoimmune diseases that preclude a diagnosis of GCA or PMR will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to establish a national database to investigate the impact of new diagnostic imaging techniques on the management of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR). It will compare treatment responses, relapse risks, and complications among patients diagnosed with these conditions. The study will utilize the RedCap database to document clinical data and imaging results, facilitating future research projects. By exploring clinical practices and biomarkers, the study seeks to improve disease control and reduce treatment-related damage.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with GCA and PMR, enhancing treatment outcomes and reducing complications.
How similar studies have gone: While limited research has been conducted on GCA and PMR, the establishment of large registries has shown promise in similar contexts, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are diagnosed with GCA or PMR within the last 5 years * Diagnosis is established by or confirmed by a rheumatologist (clinical expert opinion) * Speak and understand Danish * Are able to give signed and dated informed consent Exclusion Criteria: * Denies or are not able to give informed consent * Are diagnosed with other systemic autoimmune diseases that out-rules the diagnosis of GCA or PMR
Where it's running
-
Led og Bindevævssygdomme, Aarhus University Hospital
Aarhus, Denmark Recruiting -
Medicinsk klinik 2, Regionshospitalet Horsens
Horsens, Denmark Recruiting
Study contacts
- Principal investigator: Berit Dalsgaard Nielsen, Ass prof — Led og Bindevæv, Aarhus University Hospital, Palle Juul-Jensens Boulevard 59, 8200 Aarhus N, DK
- Study coordinator: Agnete Overgaard Donskov, MD
- Email: agnead@rm.dk
- Phone: +4530225709
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Understanding biomarkers in giant cell arteritis and polymyalgia rheumatica
This study is trying to find specific markers in the blood of people newly diagnosed with giant cell arteritis and polymyalgia rheumatica to help doctors understand their disease better and create personalized treatment plans.
-
Supplemental hydrocortisone for adrenal insufficiency during stress
This study is testing if adding hydrocortisone can help people with polymyalgia rheumatica or giant cell arteritis who have low adrenal function feel better during stressful times compared to a placebo.
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Registry and biorepository for rheumatic diseases
This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.
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Understanding genetic factors in Giant Cell Arteritis and Polymyalgia Rheumatica
This study is trying to find out if certain genes make people more likely to get Giant Cell Arteritis or Polymyalgia Rheumatica, focusing on patients aged 50 and older who have these conditions.
-
How optic nerve swelling changes after starting steroids in giant cell arteritis
This study tests how quickly the optic nerve sheath swelling decreases after starting glucocorticoids in people with newly diagnosed giant cell arteritis.
-
Sarilumab for early polymyalgia rheumatica in adults
This study tests whether sarilumab given every two weeks, with a prednisone taper, helps people with early polymyalgia rheumatica more than placebo plus prednisone taper.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.