NAIF 2.0: See if glymphatic flow changes after dAVF treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares brain MRI measurements taken before and about six months after endovascular embolization for unruptured intracranial dAVFs. The goal is to see if glymphatic system function, as seen on advanced diffusion-weighted MRI, improves following treatment. Researchers will analyze imaging markers related to perivascular spaces and brain clearance to understand potential links between venous drainage, embolization, and cognitive outcomes. Participants are adults undergoing treatment as part of standard care and will contribute imaging data within routine clinical workflows. The study builds on prior NAIF findings suggesting cognitive improvements after embolization and seeks to elucidate underlying mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 to 99 years.
* Angiographically confirmed diagnosis of unruptured intracranial dAVF.
* Candidate for endovascular embolization treatment with curative intent.
* Able to undergo Brain MRI.

Exclusion Criteria:

* Contraindication to angiographic embolization procedures.
* Acute intracranial haemorrhage secondary to dAVFs rupture and/or venous hypertension.
* Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study, other contraindications to MRI such as certain metallic implants.

Where it's running

• Hospital Universitario Vall D'Hebron
  Barcelona, Spain Recruiting
• Università di Bologna
  Bologna, Italy Not yet recruiting
• University of Oxford
  Oxford, United Kingdom Not yet recruiting

Study contacts

• Study coordinator: Laura Ludovica Gramegna, MD, PhD
• Email: laura.gramegna@vhir.org
• Phone: +34934893000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.