Multicenter chest X-ray screening for thoracic diseases
Official title: Thoracic Disease Screening Via Radiography: a Prospective Multicenter Study
Run by Chinese Academy of Sciences · NCT07585214 · Data updated 2026-11-12
This project will test whether routine chest X-rays can detect thoracic problems in adults who come for routine health examinations.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300000 (estimated) |
| Sponsor | Chinese Academy of Sciences Government |
| Locations | 1 site (Dazhou, Sichuan) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT07585214 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older presenting for routine health examinations who can give informed consent and have not had chest imaging in the past three months are ideal candidates.
✕Probably not a fit
People who are pregnant, currently receiving treatment for advanced thoracic disease, unable to hold the required position for imaging, or who had recent chest CT/X-ray are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter screening program enrolling adults presenting for routine health exams who will receive digital chest X-rays. Any suspected abnormalities on X-ray will be confirmed with a gold-standard reference such as chest CT or clinical follow-up. The primary outcome is the detection rate of confirmed thoracic conditions, and secondary outcomes include diagnostic accuracy (sensitivity and specificity), false-positive rates, and inter-center reading consistency. The study aims to provide large-cohort, real-world evidence on the feasibility and cost-effectiveness of CXR for early detection of lung, pleural, and cardiac findings to inform public health strategies.
Why it matters
Potential benefit: If successful, this could support wider use of a low-cost screening tool to identify early thoracic problems and prompt earlier care.
How similar studies have gone: Prior large studies have shown chest X-ray has limited sensitivity for early lung cancer compared with CT, though CXR has utility in some mass-screening and infectious disease contexts, and prospective multicenter evidence for broad thoracic screening remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18. * Ability to understand and willingness to sign a written informed consent form. * Individuals presenting for routine health examinations or community-based screening. Exclusion Criteria: * Women who are pregnant, lactating, or planning to become pregnant during the study period. * Physical limitations preventing stable positioning or breath-holding, or presence of metallic implants that may significantly degrade image quality. * Known history of advanced thoracic diseases currently under treatment (e.g., active lung cancer, end-stage pulmonary fibrosis, or congestive heart failure). * Individuals who have undergone chest CT or X-ray examinations within the past 3 months.
Where it's running
-
Dazhou Central Hospital
Dazhou, Sichuan, China Recruiting
Study contacts
- Study coordinator: Zeyu Zhang, Ph.D.
- Email: zhangzeyu@fingerpass.net.cn
- Phone: +86 15510661612
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.