Multicenter chest X-ray screening for thoracic diseases
Thoracic Disease Screening Via Radiography: a Prospective Multicenter Study
Chinese Academy of Sciences · NCT07585214
This project will test whether routine chest X-rays can detect thoracic problems in adults who come for routine health examinations.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese Academy of Sciences (other gov) |
| Locations | 1 site (Dazhou, Sichuan) |
| Trial ID | NCT07585214 on ClinicalTrials.gov |
What this trial studies
This is a prospective, multicenter screening program enrolling adults presenting for routine health exams who will receive digital chest X-rays. Any suspected abnormalities on X-ray will be confirmed with a gold-standard reference such as chest CT or clinical follow-up. The primary outcome is the detection rate of confirmed thoracic conditions, and secondary outcomes include diagnostic accuracy (sensitivity and specificity), false-positive rates, and inter-center reading consistency. The study aims to provide large-cohort, real-world evidence on the feasibility and cost-effectiveness of CXR for early detection of lung, pleural, and cardiac findings to inform public health strategies.
Who should consider this trial
Good fit: Adults aged 18 and older presenting for routine health examinations who can give informed consent and have not had chest imaging in the past three months are ideal candidates.
Not a fit: People who are pregnant, currently receiving treatment for advanced thoracic disease, unable to hold the required position for imaging, or who had recent chest CT/X-ray are unlikely to benefit.
Why it matters
Potential benefit: If successful, this could support wider use of a low-cost screening tool to identify early thoracic problems and prompt earlier care.
How similar studies have performed: Prior large studies have shown chest X-ray has limited sensitivity for early lung cancer compared with CT, though CXR has utility in some mass-screening and infectious disease contexts, and prospective multicenter evidence for broad thoracic screening remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18. * Ability to understand and willingness to sign a written informed consent form. * Individuals presenting for routine health examinations or community-based screening. Exclusion Criteria: * Women who are pregnant, lactating, or planning to become pregnant during the study period. * Physical limitations preventing stable positioning or breath-holding, or presence of metallic implants that may significantly degrade image quality. * Known history of advanced thoracic diseases currently under treatment (e.g., active lung cancer, end-stage pulmonary fibrosis, or congestive heart failure). * Individuals who have undergone chest CT or X-ray examinations within the past 3 months.
Where this trial is running
Dazhou, Sichuan
- Dazhou Central Hospital — Dazhou, Sichuan, China (RECRUITING)
Study contacts
- Study coordinator: Zeyu Zhang, Ph.D.
- Email: zhangzeyu@fingerpass.net.cn
- Phone: +86 15510661612
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pulmonary Diseases, Respiratory Disease, Esophageal Diseases, PROMPT, Thoracic, Screen, Radiography, Multicenter