Mulligan Movement for Acute Lateral Ankle Sprains
Official title: Unravelling the Specificity of Mulligan Mobilization With Movement on Acute Lateral Ankle Sprains: A Randomized Controlled Trial
Run by Université Catholique de Louvain · NCT07849374 · Data updated 2026-11-12
In adults with a new mild-to-moderate ankle sprain, this study tests whether Mulligan Mobilization With Movement (MWM) helps recovery compared with usual care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Université Catholique de Louvain Academic / other |
| Locations | 1 site (Gistoux, Chaumont-Gistoux) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | March 30, 2027 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07849374 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with grade I or II lateral ankle sprain within 6 weeks of onset, able to consent and participate in therapy.
✕Probably not a fit
Individuals with grade III sprains, recent immobilization, or contraindicating conditions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial enrolls adults with grade I or II lateral ankle sprains that occurred within 6 weeks, with a subset within 2 weeks of injury. Participants are assigned to either MWM delivered by trained physiotherapists or usual-care rehabilitation. The MWM group receives up to six sessions (twice weekly) where three techniques are tested in a randomized order and chosen based on a pain-free immediate response. Outcomes include range of motion, pain with weight-bearing, joint mechanics, balance, strength, and self-reported function, assessed at baseline, 3 weeks, and 3 months. The study aims to determine the clinical specificity and potential benefit of MWM for acute ankle sprains.
Why it matters
Potential benefit: If successful, patients with acute lateral ankle sprains could experience faster symptom relief and improved function with targeted Mulligan techniques.
How similar studies have gone: Other studies have explored Mulligan techniques for soft-tissue and joint mobility with some positive findings, but results can vary by condition.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Grade I or II lateral ankle sprain Index lateral ankle sprain occurring less than 6 weeks before enrollment Age 18 years or older No fracture associated with the index lateral ankle sprain No immobilization in a plaster cast Able to provide written informed consent Exclusion Criteria: * Grade III lateral ankle sprain Index lateral ankle sprain occurring 6 weeks or more before enrollment Additional lower-limb musculoskeletal disorder or injury incompatible with study participation Neurological disorder Severe hypertension Renal disease Cardiorespiratory disorder Sickle cell disease Arterial calcification Varicose veins Current anticoagulant treatment Current risk of or history of deep-vein thrombosis Fragile skin Previous surgery affecting sports performance
Where it's running
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FYKI Sports
Gistoux, Chaumont-Gistoux, Belgium Recruiting
Study contacts
- Principal investigator: Anh Phong Nguyen, PhD — CIRRIS ULaval
- Study coordinator: Hugo Bogaerts, MSc
- Email: hugo.bogaerts@uclouvain.be
- Phone: +32473954283
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.