MRI imaging of traumatic brain injury in children
Classifying Neuro-imaging Measures Predicting Rehabilitation Outcome Following Pediatric Closed Head Injuries.
This study looks at how brain scans and thinking tests can help us understand how children recover from traumatic brain injuries over a year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 9 Years to 18 Years |
| Sex | All |
| Sponsor | Sheba Medical Center Government |
| Locations | 1 site (Ramat Gan) |
| Trial ID | NCT03034031 on ClinicalTrials.gov |
What this trial studies
This project combines structural and functional MRI scans with neuropsychological assessments to evaluate cognitive recovery in children following traumatic brain injury (TBI). Over the course of a year, patients will be monitored to understand the relationship between brain imaging results and cognitive outcomes. The study aims to identify predictive measures for functional recovery and to inform personalized rehabilitation strategies. By analyzing these factors, researchers hope to gain insights into neuroplasticity and recovery processes in the developing brain.
Who should consider this trial
Good fit: Ideal candidates are children aged 9-18 who have been hospitalized for TBI and have a Glasgow coma scale score between 3-15.
Not a fit: Patients with a history of neurological disorders, psychiatric conditions, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies and better cognitive outcomes for children recovering from TBI.
How similar studies have performed: Other studies utilizing MRI and neuropsychological assessments have shown promise in understanding TBI outcomes, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients 9-18 years old, which are/were hospitalized in the Pediatric Rehabilitation Department, Sheba Medical Center 2. Glasgow coma scale score of 3-15. 3. Hebrew as mother-tongue Exclusion Criteria: 1. History of neurological disorders, mental retardation or a previous head injury. 2. Current diagnosis or history of psychiatric disorders. 3. Cardiovascular instability. 4. Metabolic instability (water, electrolytes, sugar). 5. Fever or evidence of microbiological pollutant. 6. Uncontrolled seizures. 7 . Hydrocephalus. 8. Deafness or blindness. 9. Renal failure.
Where this trial is running
Ramat Gan
- Sheba medical center Tel Hashomer — Ramat Gan, Israel (Recruiting)
Study contacts
- Principal investigator: Abigail Livny-Ezer, PhD — Sheba Medical Center
- Study coordinator: Abigail Livny-Ezer, PhD
- Email: abigail.livnyezer@gmail.com
- Phone: +972549988058
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.