MRI-derived Pressure Ratio (MPR) to predict stroke risk in intracranial atherosclerosis (ICAS)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter prospective single-arm registry enrolling 400 consecutive adults with symptomatic anterior-circulation ICAS and 50–99% stenosis. All participants receive standardized medical therapy per AHA/ASA guidelines and undergo multimodal imaging including TCD, CTA/MRA/DSA, high-resolution MRI, and phase-contrast MRA to calculate MPR. Participants are followed at baseline, 1 month, 6 months, and 12 months, with the primary outcome of ischemic stroke in the qualifying artery territory or related death within one year. An independent DSMB oversees safety and study conduct across five participating stroke centers coordinated by Xuanwu Hospital in Beijing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults aged 18 to 80 years.
2. Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation.
3. Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA.
4. Written informed consent obtained from the participant or a legal representative.

Exclusion Criteria:

1. Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities.
2. More than 50% stenosis of the extracranial carotid artery on the ipsilateral side.
3. Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3.
4. Contraindications to antiplatelet therapy or statins.
5. Inability to undergo MRI due to metal implants or claustrophobia.

Where it's running

• Department of Neurosurgery, Xuanwu hospital
  Beijing, Xicheng District, China Recruiting

Study contacts

• Study coordinator: Jichang Luo, M.D.
• Email: luojichang_dr@sina.com
• Phone: +86 13120136577

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.