Montelukast for acute bronchiolitis in infants and young children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 2 interventional trial compares montelukast to placebo in children aged 4 weeks to 2 years with acute bronchiolitis. Eligible participants must have symptom duration less than 4 days and meet clinical criteria for bronchiolitis without prior asthma or significant comorbidities. The study aims to determine if montelukast can shorten admission duration and improve clinical symptoms compared with placebo. Outcomes will be assessed during hospitalization and may inform future management strategies for acute bronchiolitis. The trial is conducted at the Pakistan Institute of Medical Sciences in Islamabad, led by the same institution.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age 4 weeks to 2 years
* Both genders
* Duration of respiratory symptoms less than 4 days
* Clinical diagnosis of acute bronchiolitis according to the operational definition provided in the study protocol

Exclusion Criteria

* History of asthma
* Previous hospital admissions for respiratory illness
* Use of asthma medications
* Congenital heart disease
* Bronchopulmonary dysplasia
* Immunodeficiency
* Immunosuppression
* Radiological evidence of pneumonia, including infiltrates or patches on chest X-ray

Where it's running

• Pakistan Institute of Medical Sciences, Islamabad
  Islamabad, Federal, Pakistan Recruiting

Study contacts

• Principal investigator: Dr Haniyah Anwar — Pakistan Institute of Medical Sciences
• Study coordinator: Dr Haniyah Anwar, M.B.B.S
• Email: haniyahanwar@yahoo.com
• Phone: +92334-8359647

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.