Monitoring the effects of chronic nitrous oxide use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the biological diagnosis and monitoring of individuals who abuse nitrous oxide, a substance linked to serious neurological disorders. It aims to identify potential biomarkers, such as vitamin B12 and homocysteine levels, that could indicate the extent of nitrous oxide exposure and its associated health risks. Participants will include current or former users of nitrous oxide, categorized based on their clinical signs and symptoms. Blood samples will be collected to analyze these biomarkers and better understand the underlying mechanisms of nitrous oxide-related health issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A current or former recreational nitrous oxide user defined
* With associated clinical signs (group 1)
* Without associated clinical signs (group 2)
* With or without clinico-biological sequelae associated with use
* Consenting to the conduct of the study
* Socially insured

Exclusion Criteria:

* Pregnant or breastfeeding women
* Never used nitrous oxide or stopped using it more than 6 months ago
* Lack of social security coverage
* Not willing to participate in the entire study

Where it's running

• Bethune
  Béthune, France Recruiting
• Boulogne Sur Mer
  Boulogne-sur-Mer, France Recruiting
• Calais
  Calais, France Recruiting
• Lens
  Lens, France Recruiting
• Chu Lille
  Lille, France Recruiting
• Nantes
  Nantes, France Recruiting

Study contacts

• Study coordinator: Guillaume Grzych, MD
• Email: guillaume.grzych@chu-lille.fr
• Phone: 0320445962

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.