Monitoring portal pressure in patients with portal hypertension
The Effect of Monitoring Portal Venous Pressure on Clinical Outcomes in Patients With Portal Hypertension: a Prospective, Single-center, Observational Study
This study is testing how measuring portal pressure can help doctors better understand and treat patients with portal hypertension caused by chronic liver disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Nanfang Hospital, Southern Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT04820166 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the clinical outcomes of patients with portal hypertension by monitoring portal venous pressure. It focuses on the hepatic venous pressure gradient (HVPG), which is considered the gold standard for predicting portal venous pressure and assessing treatment efficacy. The study will be conducted at a single center, where patients with chronic liver disease will be monitored to clarify the clinical value of portal pressure measurements. The goal is to enhance the understanding of how these measurements can guide diagnosis and treatment in affected patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-80 with chronic liver disease who require portal pressure measurement.
Not a fit: Patients with serious cardiopulmonary disease, severe renal dysfunction, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve clinical management and outcomes for patients suffering from portal hypertension.
How similar studies have performed: While the approach of monitoring portal pressure is established, the specific application and outcomes of this study may provide new insights into its clinical utility.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * With chronic liver disease * Age 18-80 years * Patients who require a portal pressure measurement at the discretion of the treating physician * Voluntarily signed informed consent Exclusion Criteria: * With serious cardiopulmonary disease or other diseases affect survival * With severe renal dysfunction * Concomitant portal vein cavernous degeneration or extensive portal vein thrombosis * Women who are planning to become pregnant or who are pregnant or breastfeeding * The researcher judged that it was not suitable to participate in this study
Where this trial is running
Guangzhou, Guangdong
- Nanfang Hospital — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Xiaofeng Zhang
- Email: 1282614092@qq.com
- Phone: +8618565552050
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.