Monitoring lung function in childhood cancer patients
Official title: Prospective Multicentre Cohort Study of Early Pulmonary Dysfunction in Childhood Cancer Patients (SWISS-Pearl Study)
Run by University Children's Hospital Basel · NCT05427136 · Data updated 2026-11-12
This study is trying to see how different cancer treatments affect lung health in children with cancer by regularly checking their lung function and symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Years to 22 Years |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | University Children's Hospital Basel Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 5 sites (Basel and 4 other locations) |
| Status | Recruiting |
| Started | June 1, 2021 |
| Main results expected | June 2051 |
| Study ends | June 2051 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT05427136 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include childhood cancer patients who have undergone treatments such as chest radiation, chemotherapy, HSCT, or thoracic surgery.
✕Probably not a fit
Patients who have not received any of the specified cancer treatments or those with respiratory insufficiency may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to prospectively monitor lung function in childhood cancer patients following their diagnosis. It will assess the impact of various cancer treatments on pulmonary dysfunction using non-invasive methods such as lung function tests, lung imaging, and breath analysis, along with clinical symptom questionnaires. The study will collect data at multiple time points to evaluate changes in lung health over time.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of pulmonary dysfunction in childhood cancer survivors.
How similar studies have gone: While this approach is observational and focuses on a specific patient population, similar studies have shown success in monitoring long-term health outcomes in cancer survivors.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * at least one of the following cancer treatments: * chest radiation * treatment with any kind of chemotherapy * hematopoietic stem cell transplantation (HSCT) * thoracic surgery * consent for Childhood Cancer Registry (ChCR) registration Exclusion Criteria: * no signed informed consent * Operation outside the chest area as only cancer treatment * Relapsed cancer (patients who develop relapse during the study will not be excluded) * In addition for MRI and lung function tests: * Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy) * Pregnant * MRI measurement not possible without sedation * Metal (e.g. pacemaker) in the body
Where it's running
-
University Children's Hospital Basel (UKBB)
Basel, Switzerland Recruiting -
Universitätsklinik für Kinderheilkunde
Bern, Switzerland Recruiting -
Geneva University Hospital
Geneva, Switzerland Recruiting -
Centre hospitalier universitaire vaudois Lausanne
Lausanne, Switzerland Recruiting -
Universitäts-Kinderspital Zürich
Zurich, Switzerland Recruiting
Study contacts
- Principal investigator: Jakob Usemann, PD Dr. med. — University Children's Hospital Basel
- Study coordinator: Jakob Usemann, PD Dr. med.
- Email: jakob.usemann@ukbb.ch
- Phone: +41 61 704 12 12
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.