Monitoring cerebral blood flow changes during anesthesia
Cerebral Perfusion Variation During Blood Pressure Changes Under General Anesthesia: Relationship Between Transcranial Doppler, Frontal EEG, and Cerebral Oximetry: a Prospective Observational Study
Assistance Publique - Hôpitaux de Paris · NCT05803876
This study is trying to see how changes in blood pressure during anesthesia affect blood flow to the brain, especially in older adults and women, to help make anesthesia safer for everyone.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Paris) |
| Trial ID | NCT05803876 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess how variations in blood pressure during general anesthesia affect cerebral perfusion. It focuses on understanding the thresholds at which hypotension impacts organ perfusion, particularly in diverse patient populations such as the elderly and women. By employing non-invasive monitoring techniques, the study seeks to identify individual responses to blood pressure changes and improve management strategies for anesthesia. The findings could lead to more personalized approaches in maintaining adequate cerebral blood flow during surgical procedures.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older scheduled for surgery at Lariboisière Hospital who consent to participate.
Not a fit: Patients under 18, pregnant women, or those opposed to participation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance patient safety by optimizing blood pressure management during anesthesia, potentially reducing postoperative complications.
How similar studies have performed: While there have been studies on blood pressure management during anesthesia, this approach focusing on individualized cerebral perfusion monitoring is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of legal age (≥ 18 years) * Eligible for scheduled surgery at Lariboisière Hospital * Informed patient who has expressed no objection to participating in this research Exclusion Criteria: * Patients under 18 years of age. * Patient opposed to participation in the protocol * Pregnant woman * Patient under judicial protection * Patient not affiliated to a social health system
Where this trial is running
Paris
- Joaquim MATEO — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Fabrice VALLEE, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Joaquim MATEO, MD
- Email: joaquim.mateo@aphp.fr
- Phone: +33 (0)149958374
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: General Anesthesia, Cerebrovascular Autoregulation, neurovascular coupling, Individualized vs Standard Blood Pressure Management Strategies, Multimodal monitoring, Brain Oxygen Saturation