Monitoring brain waves during surgery to prevent cognitive issues after surgery
The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction
This study is testing if watching brain waves during surgery can help predict if older adults will have memory or thinking problems after their operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Dartmouth-Hitchcock Medical Center Academic / other |
| Locations | 1 site (Lebanon, New Hampshire) |
| Trial ID | NCT04189861 on ClinicalTrials.gov |
What this trial studies
This research aims to determine if monitoring brain wave activity during general anesthesia can predict the likelihood of postoperative cognitive dysfunction (POCD) in patients aged 60 to 80. POCD affects a significant percentage of older adults after surgery, leading to cognitive decline that can impact daily living and overall quality of life. The study will involve patients undergoing elective, non-cardiac surgeries requiring general anesthesia and an expected hospital stay of two days or more. By understanding the relationship between brain wave patterns and cognitive outcomes, the study seeks to improve postoperative care for older adults.
Who should consider this trial
Good fit: Ideal candidates are adults aged 60 to 80 who are scheduled for elective, non-cardiac surgeries requiring general anesthesia.
Not a fit: Patients with severe mental illness, neurological disorders, or significant sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to strategies that significantly reduce the incidence of cognitive dysfunction in older surgical patients.
How similar studies have performed: Previous studies using brain wave monitoring have shown promise in understanding cognitive outcomes in surgical patients, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 60-80 years of age who present for elective, non-cardiac surgical procedure requiring general anesthesia and an anticipated two-day or longer inpatient hospital stay * English as the native and primary language * Presence of an informant who has had weekly contact with the participant for at least the last year * Participant is capable of providing written informed consent. Exclusion Criteria: * history of persistent and severe mental illness (e.g., schizophrenia, bipolar disorder) * neurological disorder (e.g., Parkinson's disease, epilepsy, stroke) * active substance use disorder as defined by the Diagnostic and Statistical Manual Diploma in Social Medicine(DSM-V) * history of prior diagnosis of learning disability per the DSM-V * estimated premorbid intellectual functioning below a scaled score of 70 based on the Test of Premorbid Functioning (TOPF) * severe visual or hearing impairments that prevent the participant from undergoing the neurocognitive assessment.
Where this trial is running
Lebanon, New Hampshire
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States (Recruiting)
Study contacts
- Principal investigator: M. Dustin Boone, MD — Dartmouth-Hitchcock Medical Center
- Study coordinator: M. Dustin Boone, MD
- Email: myles.d.boone@hitchcock.org
- Phone: 603-650-5922
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.