Monitoring adults after venous thromboembolism
Cohort for Monitoring Patients With Venous Thromboembolic Disease
This project tests whether using bleeding-and-recurrence risk scores together with multidisciplinary thrombosis meetings helps guide anticoagulant treatment for adults hospitalized with venous thromboembolism.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Rouen Academic / other |
| Locations | 1 site (Rouen) |
| Trial ID | NCT07016542 on ClinicalTrials.gov |
What this trial studies
This observational cohort enrolls adults hospitalized in the Internal Medicine department at the University Hospital of Rouen who have a confirmed deep vein thrombosis or pulmonary embolism and whose case is presented to the hospital's thrombosis multidisciplinary meeting (RCP). Investigators will collect clinical data, apply validated risk scores such as HAS-BLED, VTE-BLED, and HERDOO2, and record management decisions including anticoagulant duration and bleeding or recurrent thrombotic events. The program includes dedicated post-emergency consultations to streamline outpatient follow-up and capture outcomes. The aim is to see whether combining standardized scores with routine multidisciplinary case review leads to safer, more individualized anticoagulant care.
Who should consider this trial
Good fit: Adults (18+) hospitalized in Internal Medicine at Rouen with a confirmed DVT or PE whose case is presented at the hospital's thrombosis multidisciplinary meeting are ideal candidates.
Not a fit: Patients with thromboses excluded from the protocol (for example cerebral or mesenteric venous thrombosis), those not hospitalized or not presented to the RCP, and patients outside the inclusion criteria are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, this approach could reduce bleeding complications and better tailor how long patients stay on anticoagulants after a venous clot.
How similar studies have performed: Individual risk scores such as HERDOO2 and VTE-BLED have been validated in prior work, but the combined impact of these scores plus routine multidisciplinary RCP review on clinical management has not been widely proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Any patient over 18 years of age who has experienced at least one venous thromboembolic episode: * Deep vein thrombosis confirmed by Doppler ultrasound or CT venography, * Pulmonary embolism confirmed by CT angiography, ventilation/perfusion scan, or confirmed DVT episode with respiratory signs consistent with PE. 2. Hospitalization in the Internal Medicine Department 3. Consultation by an Internal Medicine physician 4. File presented at the thrombosis multidisciplinary meeting Exclusion Criteria: Thrombosis not meeting the inclusion criteria (cerebral venous thrombosis, mesenteric)
Where this trial is running
Rouen
- University Hospital of Rouen — Rouen, France (Recruiting)
Study contacts
- Principal investigator: Sébastien SM MIRANDA, Doctor — University Hospital, Rouen
- Study coordinator: David DM MALLET, Director
- Email: David.Mallet@chu-rouen.fr
- Phone: 02 32 88 82 65
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.