Examining blood clotting in pregnant women and the effects of low molecular weight heparin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the changes in blood clotting mechanisms during pregnancy and the postpartum period, focusing on the risk of venous thromboembolism (VTE). It aims to analyze the pharmacokinetics of low molecular weight heparin (LMWH) in pregnant women and assess how physiological changes may affect its anticoagulant efficacy. By conducting blood tests, the study will gather data on coagulation factors and the impact of LMWH treatment. The findings could help optimize anticoagulant therapy for pregnant women at risk of thrombosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Normal 1st trimester pregnancy
* Age \> 18

Exclusion Criteria:

* Coagulation disease (Von Willebrand disease, known coagulation factor deficiency before pregnancy)
* VTE history
* First-degree family history of idiopathic VTE
* Known biological risk factor for thrombosis Inherited deficiencies in coagulation inhibitors (antithrombin, protein C, protein S) Factor V Leiden polymorphism Prothrombin gene 20210G\>A polymorphism Anti-phospholipid antibodies
* Current anticoagulant use (VKA, heparins, etc.)
* Gestational diabetes detected in the 1st trimester
* Pre-existing type 1 and type 2 diabetes
* History of pathological pregnancy Premature delivery Postpartum hemorrhage Preeclampsia
* Hepatopathy
* Obesity (BMI ≥ 30)
* Infections (HIV, HBV, HCV...)
* Autoimmune diseases
* Pregnancy resulting from in vitro fertilization protocol
* Multiple pregnancy
* Patient under guardianship, curatorship or safeguard of justice
* Patient not covered by a social security scheme
* Patient deprived of liberty

Where it's running

• CHU Estaing
  Clermont-Ferrand, France Recruiting
• CHU de Clermont-Ferrand
  Clermont-Ferrand, France Not yet recruiting

Study contacts

• Principal investigator: Aurélien Lebreton — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: +33473754963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.