Modifying gut bacteria with oral sialic acid in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective cohort gives oral sialic acid to healthy volunteers and monitors changes in their gut microbiota over time. Stool samples will be collected serially and analyzed (e.g., sequencing and microbial quantification) with particular attention to growth of pathogens such as Escherichia coli and Klebsiella pneumoniae. Participants are aged 18–75, must be free of major diseases and recent antibiotics, and will be followed according to a predefined protocol. The goal is to clarify how sialic acid intake affects intestinal microbial structure and to inform strategies to preserve or restore intestinal homeostasis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged between 18 and 75 years
* No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.)
* No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.);
* Voluntarily participate in the study and sign the informed consent form.

Exclusion Criteria:

* Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.).
* Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment.
* Special populations: Pregnant women, lactating women, or women planning to become pregnant.
* Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up

Where it's running

• Second Affiliated Hospital of Army Medical University
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Study coordinator: Xiaolong Li, MD
• Email: 917304077@qq.com
• Phone: +86 15025326575

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.