Moderate CO2 increase during anesthesia to boost collateral flow in clot removal for acute anterior stroke
Official title: Evaluation of the Effect of Moderate and Controlled Hypercapnia on Ischemic Penumbra Vascular Collaterality During General Anesthesia for Anterior Circulation Acute Ischemic Stroke Mechanical Thrombectomy
Run by University Hospital, Clermont-Ferrand · NCT05051397 · Data updated 2026-11-12
This study will test whether slightly higher blood carbon dioxide during anesthesia improves collateral blood flow and protects the brain in people having mechanical thrombectomy for anterior large-vessel ischemic stroke.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | July 20, 2022 |
| Main results expected | October 20, 2028 |
| Study ends | October 20, 2028 |
| Registry record updated | September 3, 2026 |
| Trial ID | NCT05051397 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with anterior-circulation large-vessel occlusion ischemic stroke who are eligible for mechanical thrombectomy under general anesthesia and meet the trial's inclusion/exclusion criteria.
✕Probably not a fit
Patients with active smoking, chronic respiratory failure, BMI over 40, prior intubation, suspected elevated intracranial pressure, pregnancy, or posterior-circulation strokes are excluded and likely would not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized Phase 2 trial enrolls patients with anterior-circulation large-vessel occlusion ischemic stroke who undergo mechanical thrombectomy under general anesthesia. After induction and intubation, patients are randomized to moderate hypercapnia (target PaCO2 50 mmHg) or normocapnia (target PaCO2 40 mmHg) achieved by adjusting ventilator settings with arterial blood gas confirmation. Baseline and pre-reperfusion collateral circulation will be graded using the ASITN scale on angiography while systolic blood pressure and anesthetic depth are standardized. The study compares the effect of controlled CO2 modulation on collateral blood flow and periprocedural cerebral protection prior to intra-arterial revascularization.
Why it matters
Potential benefit: If successful, moderate hypercapnia during anesthesia could increase collateral cerebral blood flow before reperfusion and reduce ischemic injury, potentially improving recovery after thrombectomy.
How similar studies have gone: Physiologic and observational studies show hypercapnia increases cerebral blood flow, but randomized evidence testing CO2 modulation specifically during thrombectomy is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • Large vessel occlusion anterior circulation stroke (terminal carotid artery and/or middle cerebral artery M1-M2 segment) eligible to mechanical thrombectomy under general anesthesia Exclusion Criteria : * Active smoker * Chronic respiratory failure with ambulatory oxygen supplementation * Obesity with BMI\>40Kg/ m2 * Intubation before the procedure * Heart failure with intolerance to decubitus * Severe renal failure * Suspected elevated intracranial pressure * Pregnant or breastfeeding women
Where it's running
-
Chu
Clermont-Ferrand, France Recruiting
Study contacts
- Principal investigator: Russell Chabanne, MD MSc — University Hospital, Clermont-Ferrand
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: +33 4 73 754963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.