miR-1 as a blood biomarker for muscular dystrophies and congenital myopathies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study measures miR-1 levels in blood samples from four groups: Duchenne/Becker muscular dystrophy, myotonic dystrophy type 1, congenital myopathies, and healthy volunteers, across ages and disease severities. Investigators will compare miR-1 concentrations between groups and correlate levels with clinical severity measures. Participants provide blood samples at the CHU de Clermont-Ferrand and data are analyzed to determine whether miR-1 reliably reflects muscle disease activity. The protocol excludes recent intense exercise and treatments that could alter systemic, muscular, or cardiac biology to reduce confounding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: Participants must be older than 2 years of age
* Consent: Participants (or their legal guardians) must provide free and informed consent,. For children, the consent is oral for those under 6 years old and written for those over 6,.
* Social Security: Every participant must be affiliated with the French social security system.
* Participants must have a diagnosed neuromuscular pathology : the eligible pathologies are Myotonic Dystrophy Type 1 (DM1 or Steinert's disease), Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (DMB), or congenital myopathies or are healthy participants.

Exclusion Criteria:

* Refusal to participate expressed by the subject or their parental authority.
* Engaging in intense and unusual physical effort within 10 days before the blood draw.
* Current use of any treatment with systemic, muscular, or cardiac effects that could interfere with the study's biological results.
* Subjects or their legal guardians who are under tutelage, curatorship, deprived of liberty, or under judicial protection.
* Women who are pregnant or breastfeeding.
* The presence of an additional pathology that, in the judgment of the clinician, could interfere with the biological findings

Where it's running

• CHU de Clermont-Ferrand
  Clermont-Ferrand, France Recruiting

Study contacts

• Principal investigator: Catherine Sarret, MD, PhD, Prof — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre, PhD
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: +33473750750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.