MinION sequencing to identify microbes in diabetic foot bone infections
Official title: Evaluation of a New Diagnostic Tool (MinION) for Identifying Microorganisms in the Foot Wounds of Patients Living With Diabetic Foot Osteomyelitis (DFOM)
Run by Centre Hospitalier Universitaire de Nīmes · NCT07391995 · Data updated 2026-11-12
This study will test a rapid MinION DNA sequencing method to identify bacteria, fungi, and resistance genes in infected diabetic foot wounds and compare the results with standard culture.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 43 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nīmes Academic / other |
| Locations | 1 site (Nîmes, Gard) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | June 2026 |
| Study ends | December 2026 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT07391995 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with diabetes who have infected foot ulcers and suspected or confirmed diabetic foot osteomyelitis who can attend Nîmes University Hospital for wound/bone sampling.
✕Probably not a fit
Patients without infected diabetic foot ulcers or osteomyelitis, those unable to provide suitable wound samples, already on definitive targeted therapy, or unable to attend the study site are unlikely to benefit from this diagnostic comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will collect wound (and bone when available) samples from people with diabetic foot osteomyelitis at Nîmes University Hospital and perform real-time metagenomic sequencing using Oxford Nanopore's MinION alongside routine microbiological cultures. The MinION workflow can detect microbial genomes and predict antibiotic resistance and virulence genes in about four hours, while conventional culture methods typically take much longer. The study will compare species diversity, detection rates, and resistance/virulence profiles between the two methods to determine the additional diagnostic information provided by MinION. This is an observational comparison designed to inform potential future personalized management strategies rather than to test a therapeutic intervention.
Why it matters
Potential benefit: If successful, rapid sequencing could let clinicians identify causative microbes and resistance patterns within hours to guide more targeted antibiotic choices and reduce delays in care.
How similar studies have gone: Earlier small studies using MinION and other rapid metagenomic platforms have shown promise in quickly detecting diverse pathogens and resistance genes, but larger clinical validation is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * N/A Exclusion Criteria: * N/A
Where it's running
-
Nîmes University Hospital
Nîmes, Gard, France Recruiting
Study contacts
- Principal investigator: Adeline Dubois, Dr. — Nîmes University Hospital
- Study coordinator: Madjid MORSLI, Dr.
- Email: madjid.morsli@chu-nimes.fr
- Phone: +334 66 68 31 17
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers
This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.
-
Improving walking ability in people with diabetic nerve damage using biofeedback
This study is testing if using real-time feedback on walking can help people with diabetic nerve damage improve their walking ability and reduce the risk of serious foot problems.
-
A program providing fruit and vegetable prescriptions for diabetes management
This study is testing whether giving low-income Hispanic adults with Type 2 diabetes vouchers for fruits and vegetables, along with diabetes education, can help them manage their condition better.
-
Optimizing diabetes foot care using eHealth tools
This study is testing a new way to use digital tools to help people with diabetes take better care of their feet and prevent foot ulcers.
-
Using stem cells from fat to treat diabetic foot ulcers
This study is testing if using stem cells from fat, along with a special blood product, can help heal chronic foot ulcers in people with diabetes.
-
Effects of perturbation-based balance training vs conventional balance training for reactive stepping in adults with diabetic nerve damage
A 40-person study will test whether adding perturbation-based balance training helps adults with diabetic peripheral neuropathy react better to balance threats compared with standard balance training.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.