Minimally invasive versus open radical hysterectomy for early-stage cervical cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective multicenter study with prospective follow-up comparing long-term survival and perioperative outcomes after radical laparoscopic versus open abdominal hysterectomy performed after the LACC trial. Eligible cases are adult women with FIGO 2018 stages IB1–IIA1 (excluding IB3) and negative sentinel lymph nodes confirmed by ultrastaging. The cohort is restricted to surgeries without a uterine manipulator and with a protective vaginal cuff closure maneuver to limit tumor spill. Primary endpoints are overall survival and progression-free survival, with secondary endpoints including perioperative morbidity and recurrence patterns.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Women undergoing radical hysterectomy type B or C according to the Querleu-Morrow classification for early-stage cervical cancer (FIGO stages IB1-IIA1, excluding FIGO IB3 between November 2018 and August 2025 Not using manipulator during surgery Vaginal cuff protective maneuver during surgery Conization before surgery (optional) SNB as a first stage of treatment (optional)

Exclusion Criteria:

Women undergoing surgery for advanced stage cervical cancer (FIGO \>IIA1) or FIGO IB3 Metastasis detected in sentinel node biopsy (confirmed in ultrastaging) ECOG\>2 Not willing to participate in the study Not willing to undergo CT-scans or gynecological examinations

Where it's running

• Department of Gynaecology, Obstetrics and Gynaecological Oncology, University Clinical Centre, Medical University of Silesia
  Katowice, Poland Recruiting
• Oddział Ginekologii Onkologicznej z Pododdziałem Urologii, Opolskie Centrum Onkologii
  Opole, Poland Recruiting
• Department of Gynaecological Oncology,
  Wroclaw, Poland Recruiting
• Uniwersyteckie Centrum Onkologii, Uniwersytecki Szpital Kliniczny w Białymstoku
  Bialystok, Poland Not yet recruiting
• Klinika Ginekologii, Świętokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakład Opieki Zdrowotnej
  Kielce, Poland Not yet recruiting

Study contacts

• Study coordinator: Krzysztof Nowosielski, professor
• Email: knowosielski@sum.edu.pl
• Phone: +48 502027943

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.