Mindfulness-based treatment for obsessive-compulsive disorder
Mindfulness-Based Interventions for OCD: Efficacy, Mechanisms, and Biological Predictors of Outcome
NA · Sunnybrook Health Sciences Centre · NCT04914923
This study is testing a new mindfulness-based therapy for people with obsessive-compulsive disorder to see if it works better than standard treatments, especially for those who haven't found relief with traditional therapy.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 420 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Sunnybrook Health Sciences Centre (other) |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Trial ID | NCT04914923 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the efficacy of mindfulness-based cognitive therapy (MBCT) as a treatment for obsessive-compulsive disorder (OCD). It aims to address the limitations of traditional cognitive behavioral therapy (CBT) by incorporating mindfulness techniques, particularly for patients who have not fully responded to CBT. The study will be conducted over four years at two leading OCD treatment centers in Canada, utilizing a randomized controlled trial design to evaluate the effectiveness of MBCT compared to standard treatments. The trial will include a diverse sample of participants experiencing significant OCD symptoms.
Who should consider this trial
Good fit: Ideal candidates are individuals experiencing clinically significant obsessive-compulsive symptoms with a Yale-Brown Obsessive Compulsive Scale score greater than 17.
Not a fit: Patients with concurrent severe mood disorders, psychotic disorders, or those requiring urgent medical intervention may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new, effective option for patients with OCD who do not respond adequately to existing therapies.
How similar studies have performed: Previous studies have shown promising results for mindfulness-based interventions in treating OCD, but this trial aims to provide more robust evidence through a controlled design.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * experiencing clinically significant obsessive-compulsive symptoms based on the Yale-Brown Obsessive Compulsive Scale (YBOCS; score \> 17) * if on medications for OCD, must be stabilized, i.e. are currently receiving an adequate dose (equivalent of 40mg/day of fluoxetine) for an adequate duration (at least 8 weeks of treatment) prior to the initiation of the study. Exclusion Criteria: * concurrent diagnosis of a severe mood disorder, schizophrenia or other psychotic disorders, or substance abuse/dependence * suspected organic pathology * an active comorbid medical condition that may require urgent intervention during the treatment.
Where this trial is running
Hamilton, Ontario and 1 other locations
- St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (RECRUITING)
- Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Neil A Rector, PhD — Sunnybrook Health Sciences Centre
- Study coordinator: Neil A Rector, PhD
- Email: neil.rector@sunnybrook.ca
- Phone: 416-480-6100
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obsessive-Compulsive Disorder, Cognitive Behaviour Therapy, Mindfulness-based Intervention, Mindfulness-based cognitive therapy