Mindfulness-Based Cognitive Therapy via videoconference or self-help for preventing depression relapse

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentre randomized trial compares two delivery formats of MBCT to treatment as usual for adults with recurrent major depressive disorder, either in an acute episode or remission. Participants are allocated to group MBCT delivered via eight videoconference sessions, supported MBCT self-help with a manual and three low-intensity videoconference sessions, or TAU alone. The study measures clinical outcomes and costs at baseline, 6 months, and 12 months to assess effectiveness and potential moderators of response. It also explores mechanisms of change and predictors of who benefits most. Recruitment spans several centers in Spain, leveraging public health settings to evaluate real-world implementation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18.
* Diagnosis of recurrent major depressive disorder, with ≥ 2 previous major depressive episodes (MDD), either in an acute mild/moderate episode or in remission.
* Internet access (via smartphone or personal computer).
* Spanish literacy (spoken and written).

Exclusion Criteria:

* Current severe depressive episode (≥24 on the GRID-HAMD)
* Current or past psychosis, bipolar 1 disorder, a history of schizophrenia, schizoaffective disorder, organic mental disorder, current severe substance abuse, organic brain damage, pervasive developmental delay, persistent antisocial behaviour, recent (in the past 6 months) self-injury requiring clinical management or therapy according to medical records and clinical judgment.
* Formal concurrent structured psychotherapy during the intervention period.
* No experience in the use of new technologies (smartphones or computers).
* Having completed a mindfulness-based structured training and/or extensive meditation experience (i.e., previous participation in meditation retreats (≥1) or regular (≥ weekly) meditation practice) in the previous year, or intending to commence meditation retreats or meditation practice during the study.

Where it's running

• Hospital General Universitario de Elche
  Elche, Alicante, Spain Recruiting
• Parc de Salut Mar
  Barcelona, Barcelona, Spain Recruiting
• Fundacio Centre Higiene Mental Nou Barris
  Barcelona, Barcelona, Spain Recruiting
• Parc Sanitari Sant Joan de Déu (PSSJD)
  Sant Boi de Llobregat, Barcelona, Spain Recruiting
• Hospital Universitario Miguel Servet
  Zaragoza, Zaragoza, Spain Recruiting

Study contacts

• Principal investigator: Jesus Montero, PhD — Fundació Sant Joan de Déu
• Study coordinator: Jesus Montero, PhD
• Email: jesus.montero@sjd.es
• Phone: (34) 936 615 208 - 12733

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.