Microbial colonization and evolution in the lower airways of people with bronchiectasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect qualified sputum samples from clinically stable bronchiectasis patients every month for three consecutive years and perform metagenomic sequencing to characterize lower respiratory tract microbiome changes. Pseudomonas aeruginosa isolates will be recovered and whole-genome sequenced to analyze adaptive evolution related to virulence, quorum sensing, and drug resistance under host pressure. The team aims to link microbiome dynamics and bacterial evolution to acute exacerbations and longer-term prognosis. Findings are intended to identify microbiome-based markers and potential targets for prevention or treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Bronchiectasis patients in clinically stable period;
* Two or more chest infections in the previous year;
* Chest CT confirmed bronchiectasis (bronchial to arterial ratio \>1).
* Chronic colonization of pseudomonas aeruginosa and was clinically stable in 6 months prior to the study.

Exclusion Criteria:

* deterioration of illness (defined as at least 24 hours of three or more of the following symptoms: increased cough, increased sputum volume, purulent sputum, hemoptysis, increased dyspnea, increased wheezing, fever ((≥38°C) or discomfort, the attending physician agrees that antibiotic treatment is required);
* current smokers, or former smokers who have stopped smoking less than 1 year ago, have a history of more than 15 packets of age, or CT showed as emphysema;
* cystic fibrosis patients;
* active allergic bronchopulmonary aspergillosis;
* active tuberculosis patients;
* patients with poor asthma control;
* pregnant or breastfeeding women.

Where it's running

• 2ndAffiliated Hospital, School of Medicine, Zhejiang University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Feng Xu, Doctor
• Email: xufeng99@zju.edu.cn
• Phone: 13666697918

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.