Metacognitive therapy for anxiety and depression in autistic young people

Can Metacognitive Therapy be Used to Treat Common Mental Health Problems in Autistic Children and Adolescents: A Systematic Case Series

NA · University of Manchester · NCT05980143

This study is testing a special type of therapy for autistic kids and teens aged 11-16 to see if it can help them feel less anxious and depressed.

Quick facts

PhaseNA
Study typeInterventional
Enrollment5 (estimated)
Ages11 Years to 16 Years
SexAll
SponsorUniversity of Manchester (other)
Locations2 sites (Manchester and 1 other locations)
Trial IDNCT05980143 on ClinicalTrials.gov

What this trial studies

This study explores the effectiveness of metacognitive therapy (MCT) in treating anxiety and depression in autistic children and young people (CYP) aged 11-16. It aims to adapt the therapy to better meet the unique needs of autistic individuals, as traditional therapies may not be suitable. Participants will undergo at least eight therapy sessions, with their progress monitored through questionnaires at various stages. The study utilizes a systematic case series design to evaluate the outcomes of MCT for this population.

Who should consider this trial

Good fit: Ideal candidates are autistic children and young people aged 11-16 who are experiencing symptoms of anxiety and/or depression.

Not a fit: Patients with significant safeguarding concerns, head injuries, ADHD, or eating disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this therapy could provide a tailored approach to treating anxiety and depression in autistic young people, improving their mental health outcomes.

How similar studies have performed: While metacognitive therapy has shown promise in other populations, this specific application for autistic CYP is novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age between 11-16 years
* Consent given
* Formal diagnosis of Autism Spectrum Disorder
* Fluent in English
* Seeking treatment for emotional disorder symptoms (i.e., generalised anxiety disorder, panic disorder, agoraphobia, post-traumatic stress disorder, obsessive compulsive disorder, social anxiety; and/or depression)
* Medication for mental health problems permitted but participants must be stabilised for 6 weeks

Exclusion Criteria:

* Presence of significant risk or safeguarding concerns
* Head injury/organic impairment
* Attention Deficit Hyperactivity Disorder (formal diagnosis or under assessment)
* Eating Disorder

Where this trial is running

Manchester and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Anxiety, Depression, Anxiety symptoms, Depression symptoms, Metacognitive therapy, Children and young people, Autism

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.