Metabolic markers linked to pain and central sensitization in women with lipedema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional observational study will enroll adult women with diagnosed lipedema and chronic pain to collect metabolic markers (HOMA-IR, TG/HDL, HbA1c, fasting glucose/insulin), anthropometric measures (waist/hip circumference, BMI), and standardized pain and central sensitization assessments. Pain characterization will include intensity, pain phenotype, functional status, and validated central sensitization questionnaires, with possible quantitative sensory testing. Participants with diabetes, active endocrine or severe systemic disease, significant neurological or psychiatric disorders, or on antidiabetic or lipid-lowering medications are excluded to reduce confounding. Data analysis will examine associations between metabolic dysfunction and measures of central pain processing and clinical pain outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being female and aged 18 years or older
* Having chronic pain persisting for at least 3 months
* Having sufficient cognitive ability to understand and respond to the assessment scales used in the study
* Voluntarily agreeing to participate in the study and providing written informed consent

Exclusion Criteria:

* Presence of a history of malignancy, active infection, inflammatory rheumatic disease, or severe systemic disease
* History of known neurological disorders (e.g., stroke, multiple sclerosis, epilepsy)
* Diagnosis of severe psychiatric disorders (e.g., psychotic disorders, bipolar disorder)
* Pregnancy or breastfeeding
* Presence of cognitive impairment or communication difficulties that could affect the study results
* Diagnosed diabetes mellitus
* Active thyroid disease (uncontrolled hypothyroidism or hyperthyroidism)
* Cushing's syndrome or other significant endocrine disorders
* Use of antidiabetic medications
* Use of lipid-lowering therapy (e.g., statins, fibrates)
* Systemic glucocorticoid use within the past 3 months
* Use of medications that may significantly affect central pain mechanisms (e.g., high-dose opioids, antipsychotic drugs)
* History of major surgery or invasive treatment for pain within the past 3 months

Where it's running

• Marmara University Faculty of Medicine Pendik Training and Research Hospital
  Istanbul, Pendik, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Fatma B Akdağ
• Email: fatma.betul820@gmail.com
• Phone: +90 537 452 96 60

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.