Messaging about lower-nicotine cigarettes and related policies.
Official title: Communicating About Nicotine and Differential Risks of Tobacco Products in Priority Populations
Run by Georgia State University · NCT06787937 · Data updated 2026-11-12
This study will test whether giving adult smokers very low-nicotine cigarettes together with messages about reduced nicotine and policy changes helps them smoke less than giving the cigarettes without those messages.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 1230 (estimated) |
| Sponsor | Georgia State University Academic / other |
| Locations | 2 sites (Atlanta, Georgia and 1 other locations) |
| Status | Recruiting |
| Started | September 11, 2025 |
| Main results expected | January 31, 2029 |
| Study ends | January 31, 2029 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT06787937 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21 or older who are regular smokers (≥100 lifetime cigarettes, smoking on at least 27 of the last 30 days, and CO ≥6 ppm), can read and speak English, are available for the study period, and are willing to try research cigarettes.
✕Probably not a fit
People who are pregnant or breastfeeding, unwilling to use research cigarettes, not regular smokers, or who cannot attend weekly in-person visits are unlikely to benefit from this specific study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, open-label, two-site study comparing two groups of adult smokers who use very low nicotine cigarettes (VLNCs): one group receives VLNCs plus a campaign of messages about reduced nicotine and policy, and the other receives VLNCs with neutral, non-tobacco messages. Participants include smokers with past-month serious psychological distress (SPD), smokers with low socioeconomic status (SES), and smokers in neither category. Messaging will be delivered via cigarette-pack inserts, print ads, and videos shown at weekly visits, and all participants will attend a 1-week baseline followed by a 4-week intervention period with weekly surveys, breath CO samples, and VLNC supply. Outcomes focus on changes in cigarette use and attitudes toward VLNCs and nicotine policy.
Why it matters
Potential benefit: If successful, combining messages with very low nicotine cigarettes could help smokers reduce the number of cigarettes they smoke and shift attitudes that support nicotine-reduction policies.
How similar studies have gone: Prior clinical work has shown that very low nicotine cigarettes can reduce smoking and dependence, but combining VLNC use with a targeted messaging campaign about nicotine reduction and policy is a relatively new approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21+ years * Current smoker (self-report as having smoked 100 cigarettes in their lifetime and currently smoking on 27+ days out of past 30, expired breath carbon monoxide \[CO\] ≥6ppm to assess regular smoking) * Can speak, read, and write in English * Available for period of study * Willing to try novel research cigarettes Exclusion Criteria: * Pregnancy or lactation * Member of the same household as a study subject * Unwilling to use research cigarettes as part of the trial
Where it's running
-
Georgia State university
Atlanta, Georgia, United States Recruiting -
Emory University
Atlanta, Georgia, United States Recruiting
Study contacts
- Study coordinator: Lyudmila Popova, Ph.D.
- Email: lpopova1@gsu.edu
- Phone: 404-413-9338
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See if exposure to anti-smoking messages encourages menthol cigarette quit attempts
This study tests whether viewing anti-smoking messages in a picture-heavy choice task with eye-tracking helps adults who smoke menthol cigarettes to try to quit.
-
Mobile program to help young adults stop or cut down e-cigarette use
This project will try a smartphone program to help 18-26-year-olds who use e-cigarettes or both e-cigarettes and regular cigarettes quit or cut down.
-
Peer influence on alcohol-related sexual violence among Marine pairs
This project tries to see if a Marine's alcohol use and his drinking buddy's alcohol use and encouragement affect intentions and actions related to alcohol-involved sexual violence among male U.S. Marines.
-
Slip-and-trip motor training to reduce falls in relapsing‑remitting multiple sclerosis
This program tests whether repeated practice with controlled slips and trips helps ambulatory adults with relapsing‑remitting multiple sclerosis learn to react better and lower their chance of falling.
-
Using a humanoid robot and virtual reality games to help children with cerebral palsy improve arm function
This study is testing if a fun system using a robot and virtual reality games can help kids with cerebral palsy improve their arm movement at home.
-
Daily peanut consumption for improving health in prediabetes
This study is testing whether eating peanut butter every day can help people with prediabetes improve their health, including blood sugar levels and brain function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.