Mental imagery and symptom worsening in people with persistent post-concussive symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol recruits adults treated at Reuth Rehabilitation Hospital who have ongoing symptoms after a mild traumatic brain injury. Participants will have medical-record data collected and complete baseline clinical and cognitive screenings. They will then perform guided mental-imagery provocation tasks while symptom intensity (for example headache and dizziness) is recorded before, during, and after the tasks. The goal is to determine whether mental imagery can provoke symptoms and to shed light on perceptual or psychological mechanisms that may sustain persistent post-concussive symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Current patients of Reut Rehabilitation Hospital or individuals who were discharged from the hospital within the past 12 months.
2. Diagnosis of mild Traumatic Brain Injury, concussion, blast injury, or cervical whiplash injury.
3. More than 3 months since the event.
4. Presence of headaches and/or dizziness that began after the injury and have persisted continuously or intermittently.
5. Exclusion of other potential causes of headaches, such as non-healed fractures, chronic inflammation/infection, increased intracranial pressure, or meningeal injury.
6. Headache intensity of at least 3/10 on the VAS scale.

Exclusion Criteria:

1. Significant cognitive impairment preventing informed consent (Mini-Mental State Examination score \<20 or Montreal Cognitive Assessment score \<20, as per IRB requirements).
2. Diagnosed central neurological conditions such as multiple sclerosis, Parkinson's disease, stroke, or brain tumor.
3. Presence of known pyramidal or extrapyramidal neurological signs.
4. Significant language impairment interfering with communication.
5. Psychiatric disorders significantly affecting communication.
6. Use of vestibular-suppressant medication (e.g., Cinnarizine) with an inability or unwillingness to discontinue treatment 24 hours prior to testing.

Withdrawal Criteria:

1\. Oculomotor dysfunction affecting multiple oculomotor functions.

Where it's running

• Reuth Rehabilitation Hospital
  Tel Aviv, Israel Recruiting

Study contacts

• Principal investigator: Keren Sivan-Speier, MD — Reuth Rehabilitation Hospital
• Study coordinator: Yotam Yanai, BPT
• Email: yanayot@gmail.com
• Phone: 972523993918

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.