Measuring medication adherence in patients with acute heart failure
Adherence to Medication in Patients With Acute Decompensated Heart Failure: a Cross-sectional Study at the Emergency Department (ADHF-ED= Adherence to Medication in Patients With Acute Decompensated Heart Failure at the Emergency Department)
This study is trying to see how well patients with acute heart failure stick to their medication plans when they come to the emergency department.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universität des Saarlandes Academic / other |
| Locations | 1 site (Homburg) |
| Trial ID | NCT06459115 on ClinicalTrials.gov |
What this trial studies
This observational study aims to measure medication adherence in patients presenting with acute decompensated heart failure at the emergency department. Using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS/MS), the study will directly assess adherence rates to heart failure medications. Additionally, questionnaires will be utilized to identify patient-related factors that may influence adherence. The study focuses on patients with chronic heart failure who require intravenous diuretics and have signs of volume overload.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with known chronic heart failure requiring intravenous diuretics.
Not a fit: Patients who are unable to provide written informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of acute heart failure by identifying adherence issues and enhancing patient outcomes.
How similar studies have performed: Other studies have shown that measuring medication adherence can significantly impact treatment outcomes, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age ≥18 years of age * known chronic heart failure irrespective of ejection fraction (heart failure with reduced, mildly reduced, or preserved ejection fraction) * requirement of intravenous diuretics (outpatient or stationary treatment) * stable heart failure medication \>2 weeks * ≥1 sign of volume overload (peripheral edema, jugular venous distension, pulmonary rales, ascites, or demonstration of pulmonary venous congestion on chest X-ray) * elevated natriuretic peptides (N-terminal pro brain natriuretic peptide= nt-pro-BNP ≥125 pg/ml) Exclusion Criteria: \- Not able to give written informed consent
Where this trial is running
Homburg
- Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital Saarland, Saarland University — Homburg, Germany (Recruiting)
Study contacts
- Study coordinator: Felix Mahfoud, Professor
- Email: Felix.Mahfoud@uks.eu
- Phone: +496841 1615350
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.