Measuring lung mechanics in ventilated patients using oscillometry

Respiratory Mechanics Measurement of Ventilated Patients Through Low-frequency Oscillometry Technique, an Explorative Study

This study tests a new way to measure how well the lungs are working in patients on ventilators by using gentle pressure waves to see if it can give better information without disrupting their breathing.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 21 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Universitair Ziekenhuis Brussel (other)
• Locations: 1 site (Jette, Brussel Hoofstedelijk Gewest)
• Trial ID: NCT06483529 on ClinicalTrials.gov

What this trial studies

This study focuses on assessing respiratory mechanics in intubated patients using a low-frequency oscillometry technique. The method involves applying small pressure oscillations to measure lung impedance, which helps determine key parameters such as lung resistance and compliance. The protocol developed by the Universitair Ziekenhuis Brussel aims to provide accurate measurements with minimal interference to the patient's ventilation. This approach is particularly relevant in the context of respiratory failure, especially highlighted during the COVID-19 pandemic.

Who should consider this trial

Good fit: Ideal candidates include intubated patients on controlled ventilation who are hemodynamically stable and meet specific respiratory criteria.

Not a fit: Patients requiring assist ventilation or those with unstable respiratory conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this technique could enhance the understanding and management of ventilator lung conditions in critically ill patients.

How similar studies have performed: While the use of oscillometry is established, this specific protocol may offer novel insights and improvements over existing techniques.

Eligibility criteria

Inclusion Criteria:

* intubation
* Controlled ventilation with an intention to continue controlled ventilation for the following 4 hours.
* Richmond agitation sedation scale of -4 or less
* Hemodynamically stable patient with either

  * unchanged vasopressor dose administration for at least 60 minutes before the start of the measurements
  * no vasopressor need and no vasopressor initiated within 60 minutes of measurements
* No planned intervention in the coming 2 hours
* Survival for at least 48 hours
* Protective ventilation (inspired oxygen concentration≤60%, plateau pressure ≤30 cmH2O , driving pressure≤ 15cmH2O)
* PEEP (Positive End Expiratory Pressure) ≤10

Exclusion Criteria:

* assist ventilation
* Ventilator asynchronies
* Intermittent spontaneous breathing
* nitric oxide therapy
* presence of an extra corporeal membrane oxygenation device
* Ventilation is not possible within the lower and upper inflection point of the low flow pressure volume curve.
* Unstable right heart failure
* Unstable lung embolism
* Standard of care without Sedline® or invasive arterial catheter
* Do not reanimate code of 2, 3 or 4
* Subjects who are healthy, minors, pregnant women, patients in emergency situation
* Outside the age range 18 to 84 years

Where this trial is running

Jette, Brussel Hoofstedelijk Gewest

• Universitair Ziekenhuis Brussel — Jette, Brussel Hoofstedelijk Gewest, Belgium (RECRUITING)

Study contacts

• Principal investigator: joop jonckheer, MD, PhD — Universitair Ziekenhuis Brussel
• Study coordinator: joop Jonckheer, MD, PhD

Conditions: Ventilator Lung, oscillometry, intensive care unit, intubated patients, compliance, resistance, impedance