Measuring heart calcium levels in adults treated for childhood cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the coronary calcium score in adults who received radiation therapy to the heart area during childhood or adolescence for cancer treatment. It will compare the calcium scores of these individuals to assess whether radiation exposure is linked to increased calcium levels, while adjusting for other cardiovascular risk factors such as age, sex, and pre-existing conditions. The study focuses on patients who have been in complete remission for at least 10 years and are now adults. The primary intervention involves measuring the coronary calcium score using imaging techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients 18 years of age or older,
2. Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
3. Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate) and / or anthracycline (cumulative dose of doxorubicin equivalent ≥300mg/m\^²),
4. In complete remission of their pediatric cancer for at least 10 years,
5. Patient affiliated to a social security scheme or beneficiary of such a scheme,
6. Patient Information and Signed Informed Consent.

Exclusion Criteria:

1. Perspective less than 10 years,
2. Persons deprived of liberty or guardianship (including trusteeship),
3. Impossibility of submitting to the medical follow-up of the test for geographical, social or psychological reasons,
4. Pregnant women.

Inclusion criteria for extension cohort:

1. Patients 30 years of age or older,
2. Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
3. Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate),
4. In complete remission of their pediatric cancer for at least 10 years,
5. Patient affiliated to a social security scheme or beneficiary of such a scheme,
6. Patient Information and Signed Informed Consent.

Exclusion criteria for extension cohort:

1. Persons deprived of liberty or guardianship (including trusteeship),
2. Impossibility of submitting to the medical follow-up of the test for geographical, social or psychological reasons,
3. Pregnant women.

Where it's running

• Gustave Roussy
  Villejuif, Val De Marne, France Recruiting
• Hôpital Bichat
  Paris, France Recruiting
• Hôpital Trousseau
  Paris, France Recruiting

Study contacts

• Study coordinator: Brice FRESNEAU, MD
• Email: brice.fresneau@gustaveroussy.fr
• Phone: +33 (0)1 42 11 42 11

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.