Mapping the Left Bundle Branch Area for Pacemaker Placement
Official title: Left Bundle Branch Area Mapping for Conduction System Pacing
Run by Steward St. Elizabeth's Medical Center of Boston, Inc. · NCT05884359 · Data updated 2026-11-12
This study is testing how using 3D mapping technology during pacemaker placement can help doctors understand the heart's Left Bundle Branch Area better and improve the success of the procedure for patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 88 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Steward St. Elizabeth's Medical Center of Boston, Inc. Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | June 1, 2023 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | July 21, 2026 |
| Trial ID | NCT05884359 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 18 to 88 who are scheduled for Left Bundle Branch area pacemaker implantation.
✕Probably not a fit
Patients who are acutely ill, unstable, or have had recent heart procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to utilize 3D mapping technology to investigate the electro-anatomical and electrocardiographic features of the Left Bundle Branch Area during pacemaker implantation. By prospectively reviewing data from 30 patients undergoing this procedure, the study seeks to enhance the understanding of the anatomical characteristics of this area, which may lead to improved implantation techniques. The study will measure various electro-anatomical markers during lead placement and correlate these with the success or failure of the pacemaker implantation.
Why it matters
Potential benefit: If successful, this study could lead to more effective and precise pacemaker placements, improving patient outcomes.
How similar studies have gone: While this approach is innovative, it builds on existing knowledge of electro-anatomical mapping, and similar studies have shown promise in improving pacing techniques.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 30 consecutive patients ages 18 through 88 that undergo Left Bundle Branch area pacemaker implantation. Exclusion Criteria: * Recent MI-less than 3 months * Recent Percutaneous Coronary Revascularization-less than 2 weeks * Recent Open-Heart Procedures (CABG, Valvular procedures, etc.)-less than 1 month * Patients who are acutely ill and unstable, from the investigator's perspective, but require an urgent permanent pacemaker
Where it's running
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St. Elizabeth's Medical Center
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Michael Orlov, MD, PhD — Steward St. Elizabeth's Medical Center of Boston, Inc.
- Study coordinator: Michael Orlov, MD, PhD
- Email: Michael.Orlov@steward.org
- Phone: 617-789-3187
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Evaluating new pacing methods for heart rhythm management
This study is testing new pacing methods for heart rhythm management to see if they work better and are safer for patients who need a pacemaker or ICD.
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Left bundle branch area pacing with multimodal guidance vs. conventional pacing for heart failure with complete left bundle branch block
A multicenter trial tests whether using multimodal data to guide left bundle branch area pacing helps people with heart failure and complete left bundle branch block, compared with traditional biventricular pacing.
-
ML-based diagnosis of blocked arteries in patients with a left bundle branch block
Doctors are testing a machine learning tool that uses digital ECGs to see if a blocked coronary artery is present in patients with a left bundle branch block.
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Using ultra‑high‑frequency ECG to distinguish true LBBB and guide whether left bundle branch or biventricular pacing is best
We will test whether ultra‑high‑frequency ECG can tell 'true' left bundle branch block from other intraventricular conduction delays and see if people with heart failure and a wide non‑RBBB QRS do better with left bundle branch pacing than with biventricular pacing.
-
Evaluating different approaches to cardiac pacing in patients
This study is testing different ways to place pacemakers in adults to see which methods work best and are safest for patients needing heart support.
-
Managing new left bundle branch block after transcatheter aortic valve implantation
This compares using a one-month ambulatory ECG after TAVR with doing an immediate electrophysiology study to decide if patients who develop a new, persistent left bundle branch block need a pacemaker.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.