Mapping brain networks in children with epilepsy using advanced imaging techniques
Official title: Mapping Epileptic Networks Using Multimodal Imaging
Run by Imagine Institute · NCT06202976 · Data updated 2026-11-12
This study is testing new brain imaging methods to help doctors find the source of seizures in children with epilepsy without needing to do more invasive procedures.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Imagine Institute Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | September 14, 2017 |
| Main results expected | September 13, 2033 |
| Study ends | September 13, 2033 |
| Registry record updated | April 17, 2025 |
| Trial ID | NCT06202976 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children under 18 years old with refractory focal lesional epilepsy or rare non-lesional epilepsy who exhibit specific EEG abnormalities.
✕Probably not a fit
Patients with generalized epilepsy or those requiring sedation or general anesthesia for MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to improve the identification of the epileptogenic zone in children with focal lesional epilepsy by utilizing advanced imaging techniques such as arterial spin-labeling perfusion MRI (ASL-MRI) and resting-state functional MRI (fMRI) in conjunction with electroencephalogram (EEG). The goal is to reduce the need for invasive procedures like stereoelectroencephalography (SEEG) by accurately mapping brain activity and abnormalities. By comparing the results from these non-invasive imaging methods to the traditional SEEG reference, the study seeks to enhance pre-surgical assessments and outcomes for pediatric epilepsy patients.
Why it matters
Potential benefit: If successful, this study could lead to less invasive pre-surgical evaluations for children with epilepsy, improving their treatment options and outcomes.
How similar studies have gone: Previous studies have shown promising results using similar non-invasive imaging techniques for mapping epileptic networks, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be under 18 years of age on the day of inclusion. * Present with one of the following forms of epilepsy: * refractory focal lesional epilepsy * rare non-lesional epilepsy * Present abnormalities (spikes) on the intercritical EEG * Have been selected by the "Epilepsy" multidisciplinary staff. * In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup. * Be affiliated to a health insurance scheme. Exclusion Criteria: * Requiring general anesthesia for MRI * Require sedation specifically for research * Have generalized epilepsy * Be deprived of liberty or under guardianship.
Where it's running
-
Necker - Enfants Malades Hospital
Paris, France Recruiting
Study contacts
- Study coordinator: Nathalie Boddaert, Pr
- Email: nathalie.boddaert@aphp.fr
- Phone: +33 (0)1 44 49 51 75
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.