Mapping brain networks in children with epilepsy using advanced imaging techniques
Mapping Epileptic Networks Using Multimodal Imaging
This study is testing new brain imaging methods to help doctors find the source of seizures in children with epilepsy without needing to do more invasive procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | Imagine Institute Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06202976 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the identification of the epileptogenic zone in children with focal lesional epilepsy by utilizing advanced imaging techniques such as arterial spin-labeling perfusion MRI (ASL-MRI) and resting-state functional MRI (fMRI) in conjunction with electroencephalogram (EEG). The goal is to reduce the need for invasive procedures like stereoelectroencephalography (SEEG) by accurately mapping brain activity and abnormalities. By comparing the results from these non-invasive imaging methods to the traditional SEEG reference, the study seeks to enhance pre-surgical assessments and outcomes for pediatric epilepsy patients.
Who should consider this trial
Good fit: Ideal candidates for this study are children under 18 years old with refractory focal lesional epilepsy or rare non-lesional epilepsy who exhibit specific EEG abnormalities.
Not a fit: Patients with generalized epilepsy or those requiring sedation or general anesthesia for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to less invasive pre-surgical evaluations for children with epilepsy, improving their treatment options and outcomes.
How similar studies have performed: Previous studies have shown promising results using similar non-invasive imaging techniques for mapping epileptic networks, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be under 18 years of age on the day of inclusion. * Present with one of the following forms of epilepsy: * refractory focal lesional epilepsy * rare non-lesional epilepsy * Present abnormalities (spikes) on the intercritical EEG * Have been selected by the "Epilepsy" multidisciplinary staff. * In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup. * Be affiliated to a health insurance scheme. Exclusion Criteria: * Requiring general anesthesia for MRI * Require sedation specifically for research * Have generalized epilepsy * Be deprived of liberty or under guardianship.
Where this trial is running
Paris
- Necker - Enfants Malades Hospital — Paris, France (Recruiting)
Study contacts
- Study coordinator: Nathalie Boddaert, Pr
- Email: nathalie.boddaert@aphp.fr
- Phone: +33 (0)1 44 49 51 75
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.