Mapping blood pressure and brain blood flow during anesthesia
The Effects of Induced Hypertension on Cerebrovascular Hemodynamics During General Anaesthesia
This study tests how blood pressure affects blood flow to the brain during anesthesia to help keep patients safe during surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Umeå) |
| Trial ID | NCT06855407 on ClinicalTrials.gov |
What this trial studies
This project investigates the relationship between blood pressure and cerebral blood flow in patients undergoing general anesthesia. Participants will undergo an MRI scan to assess brain blood flow while awake before their planned surgery. The study aims to identify optimal blood pressure levels that ensure adequate brain oxygenation and perfusion during anesthesia. By understanding this relationship, the research seeks to improve management strategies for maintaining cerebral blood flow during surgical procedures.
Who should consider this trial
Good fit: Ideal candidates include patients classified as ASA 1-3, with a BMI between 18.5 and 29.9, and a Mini-Mental State Examination score greater than 23, who are scheduled for elective surgery.
Not a fit: Patients with pacemakers or other contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management of blood pressure during anesthesia, enhancing patient safety and outcomes during surgery.
How similar studies have performed: While the relationship between blood pressure and cerebral blood flow is complex, this approach is novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA classification 1-3 * BMI 18,5-29.9 * MMSE \> 23 * Elective surgery planned. Exclusion Criteria: \- Pacemaker or other contraindications for MRI.
Where this trial is running
Umeå
- Umeå University Hospital — Umeå, Sweden (Recruiting)
Study contacts
- Study coordinator: Laleh Zarrinkoob, MD, PhD
- Email: laleh.zarrinkoob@umu.se
- Phone: +46707567067
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.