Manual therapy for ankle pain in hemophilia patients
Safety and Efficacy of Manual Therapy in the Treatment of Haemophilic Arthropathy of the Ankle. A Randomised Multicentre Clinical Trial
This study tests if a hands-on treatment can help people with hemophilia and ankle pain feel better and move more easily.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 13 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Male |
| Sponsor | Investigación en Hemofilia y Fisioterapia Research network |
| Locations | 1 site (Murcia) |
| Trial ID | NCT06816056 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the safety and effectiveness of a manual therapy protocol for patients suffering from hemophilic ankle arthropathy. The study involves a randomized crossover design with 13 participants who will receive either the manual therapy or a placebo over a period of three weeks. Each therapy session lasts 50 minutes and aims to relieve pain, improve mobility, and enhance overall joint function. Participants will be assessed at the beginning, after the intervention, and during a follow-up period to measure outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with severe hemophilia A or B and diagnosed ankle arthropathy.
Not a fit: Patients with neurological or cognitive disorders that hinder their ability to participate in assessments may not benefit from this study.
Why it matters
Potential benefit: If successful, this therapy could significantly reduce pain and improve mobility for patients with hemophilic ankle arthropathy.
How similar studies have performed: While manual therapy has been explored in various contexts, this specific application in hemophilic arthropathy is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with haemophilia A and B * With severe haemophilia phenotype (\<1% FVIII/FIX) * Over 18 years of age * With a medical diagnosis of ankle arthropathy and with clinical assessment using the Hemophilia Joint Health Score * On prophylactic or on-demand treatment with coagulation factor VIII/FIX concentrates Exclusion Criteria: * Patients with neurological or cognitive disorders that prevent them from understanding the questionnaires and physical tests * Failure to sign the informed consent document
Where this trial is running
Murcia
- Universidad Católica San Antonio — Murcia, Spain (Recruiting)
Study contacts
- Principal investigator: Rubén Cuesta-Barriuso, PhD — Universidad de Oviedo
- Study coordinator: Rubén Cuesta-Barriuso, PhD
- Email: cuestaruben@uniovi.es
- Phone: 607547274
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.