Managing unruptured intracranial aneurysms with different treatment options
Official title: The Comprehensive Aneurysm Management Trial
Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT04155606 · Data updated 2026-11-12
This study is testing whether surgery or a less invasive treatment is better for people with unruptured brain aneurysms compared to just monitoring their condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) Academic / other |
| Locations | 6 sites (Edmonton, Alberta and 5 other locations) |
| Status | Recruiting |
| Started | January 15, 2020 |
| Main results expected | January 2035 |
| Study ends | January 2036 |
| Registry record updated | July 28, 2025 |
| Trial ID | NCT04155606 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with at least one documented intracranial subarachnoid aneurysm who are considering treatment options.
✕Probably not a fit
Patients with recent intracranial hemorrhage or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the long-term clinical outcomes of patients with unruptured intracranial aneurysms (UIAs) who are offered either active treatment or conservative management. It aims to determine whether surgical clipping or endovascular treatment provides better outcomes compared to conservative management for patients deemed eligible for both surgical and endovascular options. The study addresses a significant gap in current medical practice, as there are no established guidelines or evidence supporting the treatment of UIAs. By offering a comprehensive framework for patient participation, the trial seeks to clarify the best management strategies for UIAs.
Why it matters
Potential benefit: If successful, this trial could provide evidence-based guidelines for the treatment of unruptured intracranial aneurysms, potentially improving patient outcomes.
How similar studies have gone: While there have been no randomized trials comparing active and conservative management for UIAs, the study addresses a critical need in the field, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with at least one documented, intracranial subarachnoid aneurysm (cavernous aneurysms are excluded) Exclusion Criteria: * Patients with any intracranial hemorrhage, including SAH, within the previous 30 days * Patients with AVM-associated aneurysms * Patients unable to give informed consent
Where it's running
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University of Alberta Hospital
Edmonton, Alberta, Canada Recruiting -
Daniel Roy
Montreal, Quebec, Canada Recruiting -
Centre Hospitalier Régional Universitaire de Tours
Tours, France Recruiting -
ASST Ospedale Papa Giovanni XXIII
Bergamo, Italy Recruiting -
Ospedale Vito Frazzi
Lecce, Italy Recruiting -
Ospedale San Carlo Borromeo di Milano
Milan, Italy Recruiting
Study contacts
- Principal investigator: Tim Darsaut, MD — Neurosurgeon University of Alberta Health
- Study coordinator: Tim Darsaut, MD, MSc
- Email: tdarsaut@ualberta.ca
- Phone: 780-407-1440
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.