Managing blood flow after spinal cord injuries
Official title: Hemodynamic Management Following Acute Traumatic Spinal Cord Injury: A Randomized, Controlled Trial
Run by The University of Texas Health Science Center, Houston · NCT06451133 · Data updated 2026-11-12
This study is testing different ways to manage blood flow in people with recent spinal cord injuries to see which method helps them recover better and avoid other health problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 228 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | July 3, 2024 |
| Main results expected | September 15, 2025 |
| Study ends | July 31, 2026 |
| Registry record updated | December 11, 2024 |
| Trial ID | NCT06451133 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals who have sustained a traumatic spinal cord injury.
✕Probably not a fit
Patients with penetrating spinal cord injuries or severe preexisting conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates different hemodynamic management strategies to improve functional neurologic outcomes and reduce non-neurologic adverse events in patients with acute spinal cord injuries. Participants will be assigned to one of three management strategies: targeting a mean arterial blood pressure (MAP) of 85-90 mmHg, a spinal cord perfusion pressure (SCPP) of ≥65 mmHg, or maintaining normal hemodynamics with a MAP of ≥65 mmHg. The assessment will occur within the first five days following the injury to determine the effectiveness of these approaches.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery outcomes for patients with acute spinal cord injuries.
How similar studies have gone: Other studies have explored hemodynamic management in spinal cord injuries, but this specific approach is novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Traumatic spinal cord injury Exclusion Criteria: * Patients with an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection) * Preexisting neurologic or spinal cord injury * Severe traumatic brain injury as measured by a best resuscitated Glasgow Coma Scale (GCS) score of \<8 at 24 hours following injury * Presence of traumatic injuries that preclude spine surgery within 24 hours of presentation * Concomitant injury/illness requiring targeted blood pressure management (e.g., injury to the aorta, aortic dissection, hemorrhagic stroke) * Preexisting history of neuromotor disorders (i.e., cerebral palsy, Parkinson disease, etc.) * Not expected to survive \>24h * Cord transection identified by radiologist and agreed upon by the spine surgery team * Injury below spinal cord level L1 * Prisoners * Pregnant women
Where it's running
-
The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: David Meyer, MD, MS, FACS — The University of Texas Health Science Center, Houston
- Study coordinator: David Meyer, MD, MS, FACS
- Email: David.E.Meyer@uth.tmc.edu
- Phone: (713) 500-7244
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Transcutaneous spinal cord stimulation with 4-aminopyridine and intensive rehab for chronic spinal cord injury
This pilot study tests whether combining noninvasive spinal stimulation, dalfampridine, and rigorous rehab is safe and feasible for adults with chronic spinal cord injury and whether it can help improve movement and walking.
-
NG004 for incomplete cervical spinal cord injury
This trial tests NG004 versus placebo to see if it is safe and helps motor function and daily life in adults with acute incomplete cervical spinal cord injury.
-
Robot-assisted training for arm and leg movement after stroke or injury
This study tests whether adding ZEPU-AI robotic training to usual therapy is safe and helps adults with arm or leg movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions.
-
ZEPU-AI3 Lower Limb Feedback Training and Evaluation Robot in Rehab
This pilot trial tests whether adding the ZEPU-AI3 robotic leg training with real-time feedback to standard rehab helps adults with lower limb motor problems from stroke, spinal cord injury, or similar conditions.
-
Combined magnetic stimulation and ultrasound for detrusor overactivity in spinal cord injury
This study tests whether using high-frequency sacral nerve stimulation together with bladder-directed ultrasound can reduce involuntary bladder contractions and improve bladder function in people with spinal cord injury.
-
Hybrid HIIT-FES cycling program for people with spinal cord injury
This study tests a hybrid exercise program that combines functional electrical stimulation cycling with voluntary arm work to improve health in adults with spinal cord injury.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.