Lowering eye pressure to improve blood flow in glaucoma patients
Observational Study of Ocular Blood Flow Pre- and Post- Glaucoma Surgery Using Functional and Structural Optical Coherence Tomography
Oregon Health and Science University · NCT01931904
This study is testing if lowering eye pressure can improve blood flow in the eyes of people with glaucoma who are about to have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 46 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Oregon Health and Science University (other) |
| Locations | 1 site (Portland, Oregon) |
| Trial ID | NCT01931904 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate whether reducing intraocular pressure (IOP) can enhance blood flow to the eye in patients with glaucoma. Utilizing advanced high-speed ocular coherence tomography (OCT), the study will develop innovative imaging techniques to assess optic nerve head and retinal blood flow. The research focuses on correlating visual field loss with retinal blood flow measurements, potentially leading to improved diagnostic and prognostic evaluations for glaucoma. Participants will include those scheduled for trabeculectomy or tube shunt surgery.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with perimetric open angle glaucoma or chronic angle closure glaucoma who are scheduled for specific surgical interventions.
Not a fit: Patients with significant visual impairment, certain refractive errors, or other eye conditions that may complicate the evaluation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management and treatment strategies for glaucoma patients, potentially preserving vision.
How similar studies have performed: Other studies have shown promising results using similar imaging techniques, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects diagnosed with perimetric open angle glaucoma or chronic angle closure glaucoma. * Subjects scheduled to undergo trabeculectomy or tube shunt surgery Exclusion Criteria: * Best-corrected visual acuity less than 20/40 * Age \< 18 or \>85 years * Refractive error of \> +3.00 D or \< -7.00 D * Previous vision correction surgery such as Laser-Assisted in situ Keratomileusis (LASIK) or Photorefractive Keratectomy (PRK) * Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation * Diabetic retinopathy * History of heart failure, myocardial infarction, transient ischemic attack or stroke * Other diseases that may cause VF loss or optic disc abnormalities * Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil * Inability to perform reliably on automated VF testing * Life-threatening or debilitating illness making it unlikely patient will successfully complete the study. * Refusal of informed consent or of commitment to the full length of the study
Where this trial is running
Portland, Oregon
- OHSU — Portland, Oregon, United States (RECRUITING)
Study contacts
- Principal investigator: Aiyin Chen, MD — Oregon Health and Science University
- Study coordinator: Chinmay Deshpande, M.Optom.
- Email: deshpanc@ohsu.edu
- Phone: 503-494-9628
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glaucoma, IOP, Trabeculectomy