Low‑dose albumin to reduce brain damage in anterior‑circulation ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, randomized, open‑label, placebo‑controlled phase II trial enrolls patients with anterior‑circulation ischemic stroke who have an indication for vasographic intervention. Participants are randomized to receive a low‑dose albumin infusion or placebo at the time of the angiographic procedure. The timeline includes brief screening and randomization, administration during the intervention, and then ICU and ward follow-up with a primary visit at Day 90 (±7 days), for a maximum total participation of 97 days. The trial is designed to test whether albumin preserves the endothelial glycocalyx and reduces ischemic brain injury compared with placebo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ischemic stroke in the anterior circulation with or without thrombolysis administration
* vasographic intervention indication

Exclusion Criteria:

* pregnancy, breastfeeding
* known albumin hypersensitivity
* hypervolemia, hyperhydration
* hypernatremia
* another study participation

Where it's running

• University Hospital Hradec Kralove
  Hradec Králové, Czech Republic, Czechia Recruiting

Study contacts

• Study coordinator: David Astapenko, M.D., Ph.D., MBA
• Email: david.astapenko@fnhk.cz
• Phone: +420495833218

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.