Low-resistance exercise training for improving quality of life in pulmonary arterial hypertension
Official title: Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
Run by University of Pennsylvania · NCT06543745 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if a low-resistance exercise program can help improve the quality of life for people with pulmonary arterial hypertension.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT06543745 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with pulmonary arterial hypertension who have been on stable PAH therapy for at least three months.
✕Probably not a fit
Patients classified as WHO functional class IV or those with severe concomitant lung diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effects of low-resistance exercise training on the quality of life and frailty in patients diagnosed with pulmonary arterial hypertension (PAH). Participants will undergo an initial assessment of their physical performance and quality of life, followed by a 12-week home-based low-resistance training program. After the training period, participants will return for a follow-up assessment to measure any changes in their quality of life and physical performance. Caregivers will also provide feedback through exit interviews regarding their experiences with the training.
Why it matters
Potential benefit: If successful, this approach could enhance the functional ability and overall quality of life for patients with pulmonary arterial hypertension.
How similar studies have gone: Previous studies have shown positive outcomes with exercise interventions in similar patient populations, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of PAH: idiopathic, heritable, associated with connective tissue disease, congenital heart disease, human immunodeficiency virus, drug- or toxin, or portopulmonary hypertension * On stable PAH therapy for 3 months Exclusion Criteria: * World Health Organization (WHO) functional class IV * Left ventricular ejection fraction \< 40% (via transthoracic echocardiogram (TTE) within one year of screening) * Moderate or severe concomitant lung disease: Chronic Obstructive Pulmonary Disease (COPD) or interstitial lung disease * Enrollment in a clinical trial * Recent hospitalization (within 4 weeks of screening) * Inability to perform the Short Physical Performance Battery or wheelchair bound
Where it's running
-
University of Pennsyvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Nadine Al-Naamani, MD, MS — University of Pennsylvania
- Study coordinator: Zara Dunefsky, BA
- Email: zara.dunefsky@pennmedicine.upenn.edu
- Phone: 215-294-9755
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.