Low-flow sevoflurane versus desflurane for anesthesia during laparoscopic gallbladder removal
The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery
This trial will test whether low-flow sevoflurane or low-flow desflurane causes less sore throat after general anesthesia in adults having elective laparoscopic gallbladder removal.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Kayseri City Hospital Government |
| Locations | 1 site (Kayseri, Kocasinan) |
| Trial ID | NCT07440758 on ClinicalTrials.gov |
What this trial studies
This single-center, prospective, randomized controlled study will enroll ASA I–II adults aged 18–65 scheduled for elective laparoscopic cholecystectomy and randomly assign them to receive low-flow sevoflurane or low-flow desflurane anesthesia. The primary outcome is the incidence and severity of postoperative sore throat after orotracheal intubation, with secondary outcomes including postoperative hoarseness, cough, and nausea/vomiting. Endotracheal tube sizes are determined by sex and cuff pressure is standardized to 20–30 cmH2O to reduce confounding related to airway management. Patients with recent upper respiratory infection, chronic respiratory disease, pregnancy, BMI >35, known allergy to halogenated agents, or other listed exclusions are not eligible.
Who should consider this trial
Good fit: Adults aged 18–65 years with ASA physical status I–II who are scheduled for elective laparoscopic cholecystectomy, can give written informed consent, and do not meet the listed exclusion criteria are ideal candidates.
Not a fit: Patients with recent upper respiratory infection, chronic cough or respiratory disease, BMI >35, pregnancy, difficult airway predictors, prior neck/tracheal surgery, or known allergy to halogenated anesthetics are excluded and would not benefit from the study findings.
Why it matters
Potential benefit: If successful, this could identify which low-flow inhaled agent causes less postoperative throat discomfort, improving patient comfort after intubation.
How similar studies have performed: Previous studies have suggested desflurane may irritate the airway more than sevoflurane, but direct comparisons under low-flow anesthesia conditions are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-II * Aged between 18 and 65 years * Patients who provide written informed consent to participate in the study Exclusion Criteria: * Patients with a recent history of upper respiratory tract infection * Patients with a recent history of sore throat * Patients with chronic cough * Patients with a history of previous neck or tracheal surgery * Patients with predictors of difficult intubation * Patients with a history of difficult intubation * Obese patients (BMI \> 35 kg/m²) * Patients with chronic respiratory diseases (asthma, COPD) * Pregnancy * Use of dexamethasone * Patients with hepatic impairment * Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide * Patients with known allergy to halogenated anesthetic agents * Patients with a history of malignant hyperthermia * Patients with mental disorders or those unable to provide reliable assessment
Where this trial is running
Kayseri, Kocasinan
- Kayseri City Hospital — Kayseri, Kocasinan, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Şaziye Burcu Tufanoğulları Erdoğan — Kayseri City Hospital
- Study coordinator: Emine Sümeyye Akköze
- Email: smyyclk51@gmail.com
- Phone: +903523157700
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.