Low-dose beta-blocker treatment for adults who survived unexplained ventricular fibrillation
Official title: Investigation of RIsk Factors in Out-of-hospital-cardiac-arrest Patients, and MEdical Treatment in Idiopathic Ventricular Fibrillation Patients
Run by Copenhagen University Hospital, Rigshospitalet · NCT07405229 · Data updated 2026-11-12
This trial will try low-dose beta-blockers in adults who survived an out-of-hospital cardiac arrest with no clear cause to see if it reduces dangerous heart rhythms and ICD therapies.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 218 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Locations | 2 sites (Copenhagen, Dr. and 1 other locations) |
| Status | Recruiting |
| Started | May 1, 2018 |
| Main results expected | December 31, 2032 |
| Study ends | December 31, 2035 |
| Registry record updated | September 1, 2026 |
| Trial ID | NCT07405229 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) resuscitated from out-of-hospital cardiac arrest with a suspected cardiac cause but no identified ischemic or congenital heart disease who are treated at participating Danish centers and understand Danish.
✕Probably not a fit
Patients with ischemic heart disease, an obvious non-cardiac cause of arrest, congenital heart disease, those who cannot speak Danish or are foreign visitors, or those with contraindications to beta-blockers are unlikely to be eligible or to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional Phase 4 protocol gives low-dose beta-blocker therapy to adults resuscitated from out-of-hospital cardiac arrest who have no identifiable cause (idiopathic ventricular fibrillation). The primary aim is to determine whether beta-blocker treatment reduces arrhythmic events and appropriate ICD therapies during follow-up. The study also collects toxicology and genetic profiles and applies machine-learning analyses of repolarization patterns to search for predictors of recurrent arrhythmia or ICD therapy. Patients with ischemic or congenital heart disease or a clear non-cardiac cause are excluded, and recruitment occurs at two Danish tertiary centers.
Why it matters
Potential benefit: If successful, low-dose beta-blockers could lower the risk of recurrent dangerous heart rhythms and reduce ICD shocks or therapies in patients with idiopathic VF.
How similar studies have gone: Medical treatment in idiopathic ventricular fibrillation has not been systematically tested, and while some patients are treated empirically with beta-blockers, this approach remains largely unproven in formal studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Resuscitated OHCA patients admitted to one of the participating hospitals. 1. Age ≥18 years 2. Suspected cardiac cause of cardiac arrest Exclusion Criteria: OHCA patients 1. With Ischemic heart disease. 2. Obvious non-cardiac cause of cardiac arrest 3. Congenital heart disease 4. Do not speak or understand Danish 5. Foreigners -
Where it's running
-
The Heart Center, Rigshospitalet
Copenhagen, Dr., Denmark Recruiting -
Odense University Hospital
Odense, Denmark Not yet recruiting
Study contacts
- Principal investigator: Bo G Winkel, MD — The Heart Center, Rigshospitalet
- Study coordinator: Bo G Winkel, MD, PhD
- Email: bo.winkel@regionh.dk
- Phone: +4535459759
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.