Longitudinal study on Parkinson's disease in Luxembourg

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Luxembourg Parkinson's Study is an ongoing observational study that collects extensive clinical, molecular, genetic, and digital data from over 1,600 participants with Parkinson's disease and healthy controls. Participants are followed annually, with healthy controls assessed every four years, allowing for a comprehensive understanding of the disease's progression and risk factors. The study aims to create a deeply phenotyped cohort to support clinical and fundamental research on Parkinson's disease, utilizing an open-source digital platform harmonized with other international studies. This initiative includes rigorous biosampling to ensure high-quality data for future analyses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects with neurodegenerative disease or having Parkinson's disease (typical PD or atypical parkinsonism)
* Subjects of all genders with a full capacity of consent
* Subjects with a limited consent capacity if the legal guardian/authorised representative is in agreement
* Subjects of at least 18 years of age at the time of inclusion

Exclusion Criteria:

* Refusal to sign the informed consent
* Limited capacity of consent on the part of the donor, if there is no legally determined guardian/authorised representative, or the latter is not present or does not agree with the inclusion
* Active cancer
* Pregnant women
* Underage subjects of less than 18 years of age
* Refusal to comply with mandatory sample collection
* For invasive procedures, i.e., lumbar puncture and skin biopsy: relevant blood clotting impairment, e.g., anamnestic evidence of frequent or prolonged bleedings.

Where it's running

• Centre Hospitalier de Luxembourg (CHL), "Parkinson's Research Clinic"
  Luxembourg, Luxembourg Recruiting
• Clinical and Epidemiological Investigation Center (CIEC)
  Luxembourg, Luxembourg Recruiting

Study contacts

• Principal investigator: Rejko Rejko, Dr — Luxembourg Institute of Health
• Study coordinator: Rejko KRÜGER, Dr
• Email: rejko.krueger@uni.lu
• Phone: +352 44 11 4848

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.